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牙周炎患者的组织侵入性病原体及其与促炎性标记物的相关性:一个分析病例控制研究
Dhayanand J Victor1, Nirmala S Anandan2, Devapriya Appukuttan3
1Department of Periodontics, SRM Dental College, Chennai, Tamil Nadu, India, Phone: +91 9841009952, e-mail: dr.djvictor@gmail.com, Orcid: https://orcid.org/0000-0002-1631-6427.
The journal of contemporary dental practice
|January 28, 2025
概括
组织侵入性细菌存在于健康和牙周炎的部位. 这些细菌可能会对免疫系统起作用,正如在健康部位的互白素-6 (IL-6) 中所见,这表明非手术治疗是不够的.
科学领域:
- 牙周病学 牙周病学
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
背景情况:
- 牙周炎与组织侵入性细菌和炎症酶激活有关.
- 了解这些细菌和炎症标志物之间的相关性对于疾病的发病过程至关重要.
研究的目的:
- 调查组织侵入性细菌与牙周炎炎炎炎性/促炎性细胞因子上调之间的关系.
- 评估细菌存在和炎症标志物水平在牙周病的不同阶段.
主要方法:
- 从10名牙周炎患者的健康,轻度至中度和严重部位收集了组织样本.
- 评估了细菌基因组DNA和NLRP3,AIM2,TNFα,IL-1β和IL-6的基因表达.
- 分析了细菌类型和炎症标志物之间的相关性.
主要成果:
- 在严重牙周炎部位观察到较高水平的NLRP3,AIM2和促炎细胞因子.
- 大多数促炎性标志物的折叠变化在不同组中是最小的.
- 在健康部位的细菌表型与亲IL-6表达 (r=0.68,p<0.04) 之间发现了显著的相关性.
结论:
- 组织侵入性细菌存在于牙周健康部位,并在非手术治疗后持续存在.
- 组织侵入性病原体的免疫原始化可能解释健康部位的炎症标志物水平.
- 牙周炎的临床治疗应考虑牙周口袋中的软组织壁的作用.
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