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同焦点内显微镜肠上皮质屏障异常在没有记录的胃肠道疾病的个体

Thanh-Hien Trieu¹, Sophie Vieujean¹, Nicolas Delhougne¹

¹Department of Gastroenterology, CHU Liège, Liège, Belgium.

United European gastroenterology journal

|January 28, 2025

概括

基于探针的聚焦内显微镜 (pCLE) 在炎症性肠病 (IBD) 患者和非IBD患者中都显示出肠壁异常. 这些发现凸显了对这些粘膜变化的临床意义的进一步研究的需要.

科学领域:

胃肠病学胃肠病学
医疗成像医学成像
显微镜的使用方法

背景情况:

炎症性肠病 (IBD) 患者经常表现出肠上皮质屏障异常,尽管通过抗瘤缩因子或vedolizumab等疗法实现了缓解.
这些异常在非IBD个体中的存在和性质以及与IBD患者缓解中的比较仍未得到充分研究.

研究的目的:

在非IBD个体中使用基于探针的共聚焦内显微镜 (pCLE) 评估肠粘膜异常.
将这些发现与内镜缓解期的IBD患者进行比较.
识别与观察到的异常相关的因素.

主要方法:

该研究包括84名参与者:40名IBD患者在6个月以上的生物治疗和内镜缓解中,以及44名非IBD/非IBS患者接受查结肠镜检查.
白光内镜和pCLE在大肠,右结肠,横结肠,左结肠和直肠上进行.
人口,临床,生物和形态数据被收集和分析.

主要成果:

在所有检查的段落中,pCLE在两组中都发现了光素泄漏,血管扩张和高血管化等异常.
标志着皮质间隙在皮质上,以及结肠中的密室扩张.
与非IBD患者相比,IBD患者的内皮缺口略有增加,横肠光素泄漏增加,血管扩张减少.
与高血压,脂质失调,女性性别,SSRI使用以及IBD或结直肠癌家族病史相关的异常.

结论:

肠粘膜异常可以通过pCLE检测到非IBD个体和内镜缓解的IBD患者.
需要进一步研究以阐明这些发现的病理生理机制和临床影响.

关键词:

IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD IBD 生物疗法是一种生物疗法.生物学的生物学.结肠镜检查结肠镜检查结肠直肠癌是什么意思同焦点的激光内微镜.炎症性肠病是一种炎症性肠病.在健康人群中,肠道透性.一个 pCLE pCLE.缓解缓解是一种缓解.

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