在免疫受损和非免疫受损宿主中对宝贝菌病的比较结果:一个多中心队列研究
Loukas Kakoullis1,2, Carolyn D Alonso2,3, Rebecca Burns2,3
1Mount Auburn Hospital, Cambridge, MA.
概括
在免疫功能低下的患者中,宝贝菌病更为严重. 这些患者面临更高的并发症和死亡风险,目前的随访测试无法可靠地预测疾病复发.
科学领域:
- 传染性疾病 传染性疾病
- 免疫学 免疫学 免疫学
- 血液学 血液学 血液学
背景情况:
- 婴儿脊髓炎对患有免疫损害性疾病 (IC) 和阿斯普莱尼亚/低血压症 (AH) 的人来说具有重大风险.
- 了解这些易受伤害的群体与免疫能力强的个体相比的结果对于患者管理至关重要.
研究的目的:
- 为了比较患有免疫损害性疾病/失眠症/失眠症 (ICAH) 患者和没有这些患者的婴儿病的临床结果.
- 为了确定严重疾病的风险因素和babesiosis患者的复发.
主要方法:
- 一项多中心回顾性队列研究从2009年到2023年分析了225名实验室确诊的婴儿症的成年患者.
- 在ICAH患者和免疫完整的队列之间比较了临床结果,并发症和治疗方法.
主要成果:
- ICAH患者表现出更高的峰值寄生病,急性损伤,ARDS的增加率,以及更大的输血需求.
- 对于ICAH患者来说,治疗持续时间更长,12个月死亡率和婴儿病复发率显著增加.
- 血液恶性瘤和B细胞消耗疗法是复发的显著预测因素,而血涂抹和PCR测试在预测复发方面不可靠.
结论:
- 患有宝贝菌病和ICAH的患者经历更严重的疾病和更高的并发症率.
- 目前的后续检测方法不能可靠地预测高风险患者的宝宝病复发.
- 在免疫功能低下和asplenic/hyposplenic人群中,需要改进监测babesiosis复发的策略.
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