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中间轨道前皮层的结构,功能和认知与腹腔镜袖子胃切除术的体重减轻有关

Xin Li¹, Wen Zhang^1,2,3, Yan Bi⁴

¹Department of Radiology, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China.

Obesity (Silver Spring, Md.)

|January 28, 2025

概括

laparoscopic 袖子胃切除术 (LSG) 影响大脑结构和功能,特别是中间轨道前皮层 (mOFC). mOFC成像和认知评分可以预测LSG后成功的长期减肥.

科学领域:

神经科学是一个神经科学.
腹部外科腹部外科
肥胖问题研究研究

背景情况:

肥胖是一种复杂的代谢障碍,对健康有重大影响.
腹腔镜袖胃切除术 (LSG) 是一种有效的减肥手术,用于长期减肥.
在LSG后持续减肥背后的神经机制需要进一步研究.

研究的目的:

研究LSG后长期有效减肥的潜在机制.
检查LSG对中间轨道前皮层 (mOFC) 和认知功能的影响.
为了确定潜在的神经成像和认知生物标志物来预测减肥结果.

主要方法:

18名肥胖患者接受了LSG.
临床数据,认知分数和脑部MRI扫描是在LSG前和LSG后12个月收集的.
基于voxel的形态测量和静止状态功能连接 (RSFC) 分析被用于评估mOFC变化.

主要成果:

在LSG后没有观察到任何显著的一般认知改善.
LSG导致双边mOFC灰质体积减少,右边mOFCRSFC增加.
体重减轻与mOFC RSFC,一般认知和甘油三水平相关.

结论:

在LSG之后,mOFC的结构和功能变化发生.
基线mOFC灰质体积和工作记忆得分预测体重减轻的变化.
mOFC成像和认知分数可以作为LSG减肥成功的预测生物标志物.

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