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Updated: May 30, 2025

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells
06:09

Spatial and Temporal Control of Murine Melanoma Initiation from Mutant Melanocyte Stem Cells

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泰莫佐洛米德促进的MGMT转录通过激活恶性黑色素瘤中的ERK信号通路,促进化学抵抗

Meiyi Deng1,2,3, Bingjie Ren4,5, Jing Zhao6

  • 1Department of Oncology, The Fourth Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.

Journal of cellular and molecular medicine
|January 28, 2025
PubMed
概括

黑色素瘤中特莫佐洛米德 (TMZ) 耐药性与O6-甲基瓜宁-DNA甲基转移酶 (MGMT) 转录有关,该转录酶由ERK通路激活. 抑制ERK信号与vemurafenib通过降低MGMT水平和增加DNA损伤来增强TMZ的有效性.

关键词:
在MAPK/ERK路径中.在MGMT中,我们可以看到MGMT.化学电阻是一种化学电阻.黑色素瘤是一种黑色素瘤.这就是Temozolomide的含量.

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