相关实验视频

Updated: May 30, 2025

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Analysis of Interactions between Endobiotics and Human Gut Microbiota Using In Vitro Bath Fermentation Systems

Published on: August 23, 2019

肠道微生物与宿主之间的相互作用促进了Meishan猪中各种纤维成分的降解

Guang Pu¹, Liming Hou^1,2, Qingbo Zhao¹

¹Key Laboratory of Pig Genetic Resources Evaluation and Utilization (Nanjing), Ministry of Agriculture and Rural Affairs, Institute of Swine Science, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, China.

|January 28, 2025

概括

梅尚猪的纤维消化能力更好,这是由于特有肠道微生物如Treponema和Bacteroidales,以及宿主基因有助于短链脂肪酸的吸收. 这突显了宿主微生物群协同作用,用于猪中高效的纤维利用.

科学领域:

动物科学动物科学
微生物学微生物学
遗传学是一个遗传学.

背景情况:

猪肠道微生物群的研究是广泛的,但复杂的纤维降解机制和通过短链脂肪酸 (SCFA) 吸收来调节纤维消化的主机仍然不清楚.
食纤维利用效率因猪种而异,需要对潜在的宿主微生物群相互作用进行研究.

研究的目的:

调查影响梅珊 (MS) 和大白 (LW) 猪纤维降解和耐受高纤维饮食的宿主微生物群相互作用.
评估纤维消化能力的特定品种差异以及特定微生物群落和宿主基因在这个过程中的作用.

主要方法:

在MS和LW猪中进行了不同纤维含量的养实验.
多omics方法包括元基因组测序和RNA-seq.
对纤维降解产品和SCFA度在脑内光线中的分析.

主要成果:

与LW猪相比,MS猪表现出优越的纤维消化能力,特别是在高纤维饮食中.
在MS猪中,特定的微生物相互作用 (例如, *Treponema bryantii*, *Bacteroidales* 细菌 WCE2004) 促进了纤维素和点氨酸的降解.
多发性硬化猪的SCFA吸收增强,与*GPR174*和*SLC2A4*等宿主基因相关,而LW猪与微生物形状和SCFA相关基因 (*GPR183*, *GPR174*) 有不同的相关性.

结论:

主体微生物群相互作用,包括纤维和宿主SCFA运输机制的协同微生物降解,对于猪的高纤维消化能力至关重要.
这些发现为了解猪纤维利用提供了框架,并为通过肠道微生物调节提高高纤维料效率提供了理论基础.

关键词:

梅山猪是梅山人的猪.食纤维是一种食物纤维.纤维降解微生物和SCFA运输相关的候选基因.

更多相关视频

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

An In Vitro Batch-culture Model to Estimate the Effects of Interventional Regimens on Human Fecal Microbiota

Published on: July 31, 2019

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Applying Advanced In Vitro Culturing Technology to Study the Human Gut Microbiota

Published on: February 15, 2019

相关概念视频

What is Monogastric Digestion?

What is Monogastric Digestion?

The human body contains a monogastric digestive system. In a monogastric digestive system, the stomach only contains one chamber in which it digests food. Several other animal species also have monogastric digestive systems, including pigs, horses, dogs, and birds. This chapter, however, focuses on the human digestive system.

Bacterial Flora of the Large Intestine

Bacterial Flora of the Large Intestine

The gut microbiome is formed by a vast and diverse community of bacteria that colonizes our large intestine. These bacteria start residing in the gut from birth and continue diversifying throughout life, influenced by factors such as diet, lifestyle, and stress. The gut bacterial community also includes bacteria from food and those that enter the colon through the anus.
The normal gut flora of the colon plays a critical role in generating essential vitamins such as vitamins K, B5, and B7.