瓦尔酸诱导的高氨血症与成人脑病变:一个元分析
International journal of clinical pharmacology and therapeutics
|January 28, 2025
概括
酸治疗可能导致高氨血症 (HA),特别是在,心力衰竭,或与phenytoin结合时. 监测氨和酸水平对于预防超氨性脑病变 (HE) 至关重要.
科学领域:
- 药理学 药理学是指药理学的学科.
- 神经学 神经学
- 临床医学 临床医学
背景情况:
- 瓦尔酸是用于治疗神经和精神疾病的广泛使用的药物.
- 超血 (HA) 是一种已知的酸治疗的不良影响.
- 鉴定HA的风险因素对于患者的安全至关重要.
研究的目的:
- 为了研究患者特征,并发症,并发药物,以及在接受酸治疗的患者中发展超氨血病 (HA) 的风险之间的关联.
- 为了确定酸诱导的HA的独立风险因素.
主要方法:
- 回顾性研究分析了接受酸监测的成年患者的医疗记录 (2019年1月 - 2021年12月).
- 具有HA和没有HA的患者的比较.
- 多变量后勤回归分析和系统文献审查以确定风险因素.
主要成果:
- 在247名患者中,有37名患有HA (血清氨量>150mcg/dL),其中大多数进展为超氨性脑病变 (HE).
- 对HA的独立风险因素包括 (OR: 3.82),充血性心力衰竭 (OR: 32.3) 和同时使用芬伊托因 (OR: 6.4).
- 酸水平与氨水平呈正相关性,同时使用托皮拉也与HA有关.
结论:
- 在治疗酸期间,应定期监测血清氨和酸水平.
- 密切监测对于患有,心力衰竭或同时使用芬伊托因或托皮拉的患者尤为重要.
- 积极的监测可以帮助预防高血性脑病变 (HE) 的进展.
相关概念视频
Anticholinesterase Agents: Poisoning and Treatment
813
Anticholinesterases, also known as cholinesterase inhibitors, work by blocking the breakdown of acetylcholine, leading to its accumulation in the synaptic cleft. This accumulation indirectly enhances both muscarinic and nicotinic actions. These agents are classified as reversible or irreversible based on their mechanism of action.
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
Irreversible agents form a strong bond with the cholinesterase enzyme, making it inactive. The breakdown of the phosphorylated enzyme is...
813
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
273
Antiepileptic drugs, such as levetiracetam (Keppra) and brivaracetam (Briviact), have emerged as crucial tools in managing epilepsy. These medications exert their therapeutic effects by targeting the synaptic vesicle protein SV2A, a transmembrane glycoprotein primarily found in the brain.
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
273
Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance
104
The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
A study on guinea pigs examined the...
A study on guinea pigs examined the...
104
Antiepileptic Drugs: GABAergic Pathway Potentiators
349
γ-aminobutyric acid or GABA, plays a pivotal role as an inhibitory neurotransmitter in the brain. GABA pathway potentiators, also known as GABAergic drugs, are a class of pharmaceutical agents designed to enhance the functioning of the GABAergic system. These medications primarily treat epilepsy, a neurological disorder characterized by recurrent seizures.
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
The key GABA pathway potentiators used in epilepsy management are as follows.
Benzodiazepines are a well-known class of drugs used for...
349
Antiepileptic Drugs: Glutamate Antagonists
300
Glutamate is a fundamental neurotransmitter in the central nervous system, playing a vital role in neuronal communication and various cognitive processes. Glutamate stands as the principal excitatory neurotransmitter in the brain. Its presence is crucial for the communication between neurons, underpinning essential processes such as synaptic transmission, neuronal excitability, and plasticity. These functions are vital for higher-order cognitive processes, including learning and memory. The...
300
Prevention of Further Absorption of Poison
801
In cases of acute poisoning, the primary objective is to prevent further absorption of the toxic substance into the body. Immediate interventions using various decontamination techniques targeting the gastrointestinal (GI) tract can achieve this. Decontamination is crucial to prevent poison from entering the systemic circulation, which involves washing affected areas with water and mild soap and removing contaminated clothing. Once external decontamination is done, attention must be turned to...
801


