比斯德梅托西库尔库和库尔库通过维持肠道上皮质完整性和调节小鼠肠道微生物群来缓解炎症性肠病
Kai-Yu Hsu1, Anju Majeed2, Chi-Tang Ho3
1Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan.
Journal of agricultural and food chemistry
|January 28, 2025
概括
来自黄的化合物Bisdemethoxycurcumin (BDMC) 在炎症性肠病 (IBD) 中表现出强大的抗炎作用. BDMC改善了肠道屏障功能和微生物平衡,提供了有前途的治疗潜力.
科学领域:
- 自然产品 化学 化学
- 胃肠病学 胃肠病学
- 免疫学 免疫学 免疫学
背景情况:
- 库尔库米诺酸,包括黄素 (CUR) 和双甲黄素 (BDMC),都来自黄 (Curcuma longa L.).
- 虽然CUR得到了充分的研究,但BDMC的抗炎性质,特别是在炎症性肠病 (IBD) 中,理解程度较低.
- 在临床前模型中,BDMC表现出更强的NF-κB抑制,并且比CUR更有效地准IBD相关途径.
研究的目的:
- 评估和比较CUR和BDMC在DSS诱导大肠炎的小鼠模型中的治疗效果.
- 研究CUR和BDMC对肠道屏障功能,炎症,肠道微生物群和短链脂肪酸 (SCFA) 生产的影响.
主要方法:
- 使用德克斯硫酸 (DSS) 诱导的大肠炎小鼠模型来评估饮食CUR和BDMC的影响.
- 分析包括疾病活性评分,组织学检查,紧结 (TJ) 蛋白质的评估,炎症性细胞因子水平,肠道微生物群组成和SCFA概况.
- 还研究了CUR和BDMC之间关于吸收和分泌的药理动力学差异.
主要成果:
- 无论是CUR还是BDMC,都加强了肠道紧结蛋白,减少了炎症性细胞因子分泌,缓解了DSS诱导的IBD.
- CUR和BDMC调节了肠道微生物群,增加了生产酸盐的细菌的丰富性,并调节了微生物失衡.
- 与CUR相比,BDMC的吸收水平较高,主要通过便排出.
结论:
- 无论是BDMC还是CUR,都显示出作为IBD辅助疗法的潜力.
- 特别是0.1%的BDMC具有显著的抗炎作用,并增强肠道屏障完整性 (TJ蛋白).
- 由于其增强的吸收和有效性,BDMC对IBD具有有前途的治疗潜力,即使度低于CUR,由于其增强的吸收和有效性.
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