在COVID-19感染后,大脑中的白物质通路的扩散张力成像特征
Serdar Balsak1, Bahar Atasoy2, Fatma Yabul3
1Department of Radiology, Bezmialem Vakıf University, Istanbul, Turkey. serdar.balsak@gmail.com.
Radiologie (Heidelberg, Germany)
|January 28, 2025
概括
根据扩散张力成像 (DTI) 变化,COVID-19感染可能会导致大脑白质道的微结构损伤. 这种损伤,特别是在体中,与氧气和水平相关.
科学领域:
- 神经成像是一种神经成像.
- 神经学 神经学
- 放射学 放射学是一门学科.
背景情况:
- 在COVID-19患者中观察到神经系统并发症.
- 扩散张力成像 (DTI) 用于评估白质的完整性.
研究的目的:
- 在COVID-19的亚急性阶段,调查白质通路中明显扩散系数 (ADC) 和微分异构 (FA) 值的差异.
- 在COVID-19患者中探索DTI指标和实验室发现之间的相关性.
主要方法:
- 在91名COVID-19患者和64名健康对照中计算了10个神经解剖学位置的DTI指标 (ADC和FA).
- 患者被分为所有患者,门诊患者和住院患者组.
- 在这些组中和对照组中比较了DTI值.
主要成果:
- COVID-19患者在几个白质道中表现出降低的FA值,包括带膜,体和大.
- 在患者,特别是住院患者的体 (CCG) 中观察到ADC值升高.
- 在CCG和上前后囊 (SFOF) 中,氧和度和FA值之间发现了正相关性.
结论:
- DTI的发现表明,在COVID-19的亚急性阶段,微观结构损伤和白质完整性受损.
- 这些白质变化可能与轴突损伤和脱髓化有关.
- 观察到的损伤与氧和水平相关,需要进一步研究长期影响和神经认知结果.
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