tRNA m1A 修改调节胆固醇生物合成,以促进 CD8+ T 细胞的抗瘤免疫力

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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity

Published on: January 7, 2019

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Shan Miao1,2, Hao Li3, Xiaohan Song1,2

  • 1Center for Immune-Related Diseases at Shanghai Institute of Immunology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai, China.

The Journal of experimental medicine
|January 28, 2025
PubMed
概括

由Trmt61a调节的tRNA m1A修饰通过促进胆固醇合成来增强CD8+T细胞抗瘤免疫力. 这一发现为癌症免疫治疗策略提供了新的途径.

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