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Updated: May 30, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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在携带TP53生殖系变异的携带者中,癌症风险被分为不同的功能类别

Lucas John Müntnich1, Christina M Dutzmann1, Anika Großhennig2

  • 1Pediatric Hematology and Oncology, Hannover Medical School, 30625 Hannover, Germany.

JNCI cancer spectrum
|January 28, 2025
PubMed
概括

癌症倾向的Li-Fraumeni综合征与TP53变种有关. 变体功能影响癌症发病,部分功能变体和B/C集群与晚期诊断相关,有助于风险分层.

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