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Updated: May 30, 2025

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Measuring Cardiac Autonomic Nervous System ANS Activity in Children
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在接受慢性血液透析的儿童中,缩和扩张功能障碍与自主神经系统功能之间的关联
Ola H Abd Elaziz1, Ghada M S Ahmad1, Salwa S Abd Elgawad2
1Cardiology Department, Faculty of Medicine (Girls), Al-Azhar University, Cairo, Egypt.
Pediatric nephrology (Berlin, Germany)
|January 28, 2025
概括
患有慢性病 (CKD) 接受血液透析 (HD) 的儿童心脏功能减弱和自主功能障碍. 心肌变形损伤和心率变化预测这些儿科患者的死亡率更高.
科学领域:
- 儿童心脏病学 儿童心脏病学
- 腎臟病學 (nephrology) 是一種醫學.
- 心血管生理学心血管生理学
背景情况:
- 心脏功能和自主神经系统的关联在接受血液透析 (HD) 的5期慢性病 (CKD) 的儿童中不明.
- 了解这些变化对于治疗末期病的儿科患者至关重要.
研究的目的:
- 为了研究心脏结构,功能和自主神经系统活动在儿童5期CKD接受HD.
- 确定这个脆弱人群中死亡率的预测因素.
主要方法:
- 一项前性观察队列研究,涉及40名患有CKD的埃及儿童和40名健康对照.
- 使用2D/4D心声回声,24小时霍尔特监测和临床/实验室评估.
- 在36个月内,对参与者的死亡率和发病率进行了跟踪.
主要成果:
- 患有CKD和HD的儿童在HD后显著减少左室和右室缩功能,心率变化受损.
- 全球纵向应变 (GLS) 和心率变化参数 (rMSSD) 与心脏自主功能相关.
- 减少LV/RV-GLS和减少rMSSD是死亡率的独立预测因素,观察到25%的死亡率.
结论:
- 患有CKD的儿童的血液透析导致心肌变形 (LV/RV-GLS) 和心脏自主功能障碍的减少.
- 增加了同情性和降低了阴道活动.
- 减少LV/RV-GLS和rMSSD是儿科HD患者死亡率的显著独立预测因素.
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