常规的抗生素是否会改变骨髓瘤细胞感染率? 一个案例系列
Cilmária Leite Franco1, Jairo Porfirio de Oliveira Júnior2, Bárbara Albuquerque Morais3,2
1Department of Neurological Surgery, Children's Hospital, Goiânia, Brazil. cilmariafranco@hotmail.com.
概括
及时的手术和预防性抗生素显著降低了新生儿中枢神经系统 (CNS) 感染的风险,在修复后患有骨髓瘤 (MMC). 延误和缺乏抗生素增加了感染率,强调了标准化的护理.
科学领域:
- 儿科手术 儿科手术
- 新生儿护理 新生儿护理
- 传染病流行病学 传染病流行病学
背景情况:
- 骨髓炎 (MMC) 是一种常见的先天性脊柱形,需要手术干预.
- 虽然产前修复正在获得青,但产后修复仍然是许多医疗机构的标准方法.
- 这项研究调查了抗生素使用对中枢神经系统 (CNS) 感染率的影响,在新生儿产后的MMC修复后.
研究的目的:
- 评估给患有骨髓瘤细胞 (MMC) 的新生儿开的抗生素.
- 确定抗生素使用与中枢神经系统 (CNS) 感染率在手术后之间的相关性.
- 确定影响产后MMC修复的新生儿感染结果的因素.
主要方法:
- 对接受产后MMC修复的新生儿进行回顾性队列研究 (2017年8月 - 2021年6月).
- 怀孕,分娩,解剖学和神经外科变量的分析.
- 根据手术修复的时间 (在24,48,72小时内和72小时以后) 来对新生儿进行分类,以评估中枢神经系统感染率.
主要成果:
- 包括38名新生儿;24.32%的中枢神经系统在手术后发生感染.
- 22.86%的母亲缺乏产前护理;剖腹产占主导地位 (77.78%).
- 手术的平均时间为67小时; 73.68%的患者在入院时发生了膜破裂; 78.94%的患者接受了输液抗生素.
结论:
- 及时的手术干预和预防性抗生素对于降低患有MMC的新生儿中枢神经系统感染率至关重要.
- 手术延迟和缺乏抗生素预防与感染率增加相关.
- 建议采用标准化护理协议和加强产前护理,以优化MMC新生儿的治疗结果.
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