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Updated: May 8, 2025

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
05:51

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia

Published on: June 15, 2011

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与精神媒介相关的候选基因:对高度天赋的媒介进行全外测序分析

Wagner Farid Gattaz1, Marianna de Abreu Costa2, Angélica Salatino-Oliveira3

  • 1Laboratory of Neurosciences (LIM-27), Department and Institute of Psychiatry, São Paulo Medical School, University of São Paulo, São Paulo, SP, Brazil. Instituto Nacional de Biomarcadores em Neuropsiquiatria, Department and Institute of Psychiatry, São Paulo Medical School, University of São Paulo, São Paulo, SP, Brazil.

Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)
|January 28, 2025
PubMed
概括

精神媒介可能与独特的遗传变异有关. 这项研究发现介质中存在的特定基因变异不在它们的亲属中,这表明这些经验的潜在生物基础.

关键词:
异源 (exome) 是指外源 (exome) 的一个部分.异常经历是一种异常的经历.基因 基因 基因 基因媒介船 媒介船 是一个媒介船.有精神经验,有精神经验.

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A Novel Strategy Combining Array-CGH, Whole-exome Sequencing and In Utero Electroporation in Rodents to Identify Causative Genes for Brain Malformations08:22

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Genome-wide association studies or GWAS are used to identify whether common SNPs are associated with certain diseases. Suppose specific SNPs are more frequently observed in individuals with a particular disease than those without the disease. In that case, those SNPs are said to be associated with the disease. Chi-square analysis is performed to check the probability of the allele likely to be associated with the disease.
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Exon Recombination

The evolution of new genes is critical for speciation. Exon recombination, also known as exon shuffling or domain shuffling, is an important means of new gene formation. It is observed across vertebrates, invertebrates, and in some plants such as potatoes and sunflowers. During exon recombination, exons from the same or different genes recombine and produce new exon-intron combinations, which might evolve into new genes. 
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