最近和终身大麻使用的大脑功能结果
Joshua L Gowin1,2, Jarrod M Ellingson2, Hollis C Karoly3
1Department of Radiology, University of Colorado Anschutz Medical Campus, Aurora.
JAMA network open
|January 28, 2025
概括
年轻人大量使用大麻与工作记忆任务期间大脑活化减少有关. 这表明,即使在健康个体中,对认知功能也有潜在的长期负面影响.
科学领域:
- 神经科学是一个神经科学.
- 认知科学 认知科学
- 成研究 研究成研究
背景情况:
- 全球大麻使用量正在上升,需要对其神经效应进行研究.
- 了解大麻对大脑功能的长期影响至关重要.
- 以前的研究还没有完全阐明与大麻使用相关的大脑激活模式.
研究的目的:
- 调查一生重度使用大麻和最近使用大麻与年轻成年人大脑激活之间的关联.
- 在与大麻消费模式相关的各种认知任务中分析大脑功能.
- 为了确定受不同程度的大麻使用影响的特定大脑区域.
主要方法:
- 使用人类连接组项目数据 (2012-2015年) 进行的横截面研究.
- 包括1003名年轻成年人 (年龄22-36岁) 的MRI,毒理学和大麻使用数据.
- 评估一生重度大麻使用 (>1000次使用) 和最近通过尿液毒理学使用;在7个功能性MRI任务中分析了大脑激活.
主要成果:
- 严重的终身大麻使用与工作记忆任务中的大脑激活显著降低有关 (Cohen d = -0.28,P = .02).
- 受影响的大脑区域包括前脑岛,中间前额叶皮质和后侧前额叶皮质.
- 最近的大麻使用显示出与工作记忆和运动任务的表现较差和激活较低的关联,但这些在校正后没有达到统计学意义.
结论:
- 长期大量使用大麻与年轻成年人在工作记忆任务期间大脑激活的减少有关.
- 这些发现表明,大量使用大麻对认知功能可能会产生持久的负面影响.
- 需要进一步的研究来了解大麻消费的长期神经学影响.
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