患有周产期艾滋病毒暴露和感染的年轻成年人中中心动脉硬
Elaine M Urbina1, Wendy Yu2, Paige L Williams2,3
1Cincinnati Children's Hospital Medical Center and the University of Cincinnati, Cincinnati, Ohio.
AIDS (London, England)
|January 28, 2025
概括
通过脉冲波速度 (PWV) 测量的动脉硬度,在患有围产期获得的艾滋病毒 (YAPHIV) 和暴露但未感染 (YAPHEU) 的年轻人之间没有显著差异. 建议所有年轻成年人减少心血管风险.
科学领域:
- 心脏病学 心脏病学
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
背景情况:
- 患有围产期获得的艾滋病毒 (YAPHIV) 的年轻人可能面临独特的健康挑战.
- 在这个人群中评估心血管健康对于长期结果至关重要.
研究的目的:
- 为了比较动脉硬度,一个关键的心血管风险指标,在YAPHIV和年轻成年人之间与周围暴露但未感染的HIV (YAPHEU).
主要方法:
- 在150名参与者 (95名YAPHIV,55名YAPHEU) 中,脉冲波速度 (PWV) 和心声回声图的横截面分析.
- 两组之间PWV的比较.
- 线性回归模型评估了艾滋病毒疾病严重程度和抗逆转录病毒治疗 (ART) 与YAPHIV中PWV的关联.
主要成果:
- 平均PWV在YAPHIV (5.63 m/s) 和YAPHEU (5.39 m/s) 之间是相似的.
- 大多数YAPHIV患者具有良好的HIV控制 (82%的病毒载量<400副本/毫升) 并使用组合ART (91%).
- 在PWV和心声测量之间发现了微弱的相关性;艾滋病毒的严重程度和ART类型与PWV没有显著的关联.
结论:
- 在YAPHIV和YAPHEU之间没有观察到动脉硬度 (PWV) 的显著差异.
- 目前的艾滋病毒管理似乎保持正常的动脉硬性在YAPHIV.
- 遵守心血管风险降低指南对于所有年轻成年人来说都是必要的,以预防心血管疾病.
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