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亚斯巴酸代谢驱动的肠道微生物群动力学和RIP依赖的线粒体功能抵消氧化应激

Shunshun Jin^1,2, Jian Wu³, Chenyu Wang^1,3

¹Hunan Provincial Key Laboratory of Animal Intestinal Function and Regulation, Hunan international joint laboratory of Animal Intestinal Ecology and Health, Laboratory of Animal Nutrition and Human Health, College of Life Sciences, Hunan Normal University, Changsha, 410081, China.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

|January 28, 2025

概括

阿斯巴酸盐 (Asp) 代谢通过调节微生物群和产生抗氧化剂来增强肠道健康. 这改善了肠道功能,并与氧化压力作斗争,提供了一种新的治疗方法.

科学领域:

生物化学生物化学
微生物学微生物学
细胞生物学细胞生物学

背景情况:

酸盐 (Asp) 代谢对新生儿生长和肠道健康至关重要.
在氧化应激下,Asp调节肠道微生物群和RIP信号的机制尚不清楚.

研究的目的:

阐明Asp代谢在调节肠道微生物群和RIP激活中的抗氧化机制.
研究ASP在氧化应激期间对肠道健康的作用.

主要方法:

在体内和体外使用外源Asp的研究.
对肠道微生物群组成的分析 (例如,Megasphaera,Ruminococcaceae).
对包括RIP3-MLKL,RIP1-Nrf2-NF-κB在内的分子通路的研究,以及抗氧化剂生产 (eicosapentaenoic acid).

主要成果:

外源性ASP通过调节上皮细胞增殖,营养摄取和正常情况下的亡来改善肠道健康.
在氧化压力期间,Asp转移肠道微生物群,减少Megasphaera和增加Ruminococcaceae.
这种转变增强了eicosapentaenoic酸的产生,并调节了依赖RIP的通路,以减少活性氧物种并维持线粒体功能.

结论:

阿斯普信号通过动态调节肠道微生物群和依赖RIP的线粒体功能来减轻氧化压力.
Asp代谢代表了治疗氧化压力相关疾病的潜在治疗策略.

关键词:

在 RIP 路径上.亚斯巴酸盐是一种我们的微生物群.氧化应激是一种氧化应激.

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