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A Syngeneic Mouse B-Cell Lymphoma Model for Pre-Clinical Evaluation of CD19 CAR T Cells
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CD19-CAR T细胞疗法诱导B细胞的深层组织枯竭

Carlo Tur1, Markus Eckstein2, Joachim Velden3

  • 1Department of Medicine 3-Rheumatology and Immunology, Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany; Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität (FAU) Erlangen-Nürnberg and Uniklinikum Erlangen, Erlangen, Germany, Erlangen, Germany; Division of Rheumatology-Fondazione Policlinico Universitario A. Gemelli, IRCCS-Università Cattolica del Sacro Cuore, Roma, Lazio, Italy.

Annals of the rheumatic diseases
|January 28, 2025
PubMed
概括

CD19-CAR T细胞疗法有效地消除了自身免疫性疾病患者淋巴结和非淋巴细胞器官中的B细胞. 这证实了深层组织B细胞的枯竭,支持自身免疫性疾病的长期缓解.

关键词:
自免疫性疾病 自免疫性疾病乙型淋巴细胞是B型淋巴细胞.里图西马布 (Rituximab) 是一种药物.超声波学 超声波学 超声波学

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