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Updated: May 30, 2025

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase
10:33

Efficient Purification and LC-MS/MS-based Assay Development for Ten-Eleven Translocation-2 5-Methylcytosine Dioxygenase

Published on: October 15, 2018

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新型白血病衍生的突变TET2酶诱导基因组不稳定性通过基底转移从5-甲基酸到胺

Guang-Bo Jin1, Shao-Qin Rong1, Dong-Rui Yin1

  • 1Shanghai Key Laboratory of Medical Epigenetics, Institutes of Biomedical Sciences, Chinese Academy of Medical Sciences (RU069) and Zhongshan-Xuhui Hospital, Medical College of Fudan University, Shanghai 200032, China.

Proceedings of the National Academy of Sciences of the United States of America
|January 28, 2025
PubMed
概括

在白血病患者中,某些十-十一转位2 (TET2) 突变获得了新的功能,氧化胺而不是5-甲基细胞因. 这种新型活动有助于DNA损伤和白血病发生.

关键词:
这就是TET2突变.哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈哈这种白血病是白血病.新形态活动的新形态活动.乙胺氧化氧化过程

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