菲普罗尼尔在次致命剂量下会导致 brojiler鸟类的免疫毒理学效应
Shafia Tehseen Gul1, Muhammad Zergham Tahir1, Latif Ahmad2
1Department of Pathology, Faculty of Veterinary Science, University of Agriculture, Faisalabad, Pakistan.
PloS one
|January 28, 2025
概括
暴露于菲普罗尼尔杀虫剂会损害家禽的免疫力,减少抗体的产生,并损害重要的淋巴体器官,如Fabricius的毛囊,胸腺和脏. 这项研究突出了fipronil对的毒性影响,即使在低剂量.
科学领域:
- 兽医毒理学 兽医毒理学
- 免疫学 免疫学 免疫学
- 禽畜科学 禽畜科学 禽畜科学
背景情况:
- 杀虫剂,如fipronil,在农业和兽医应用中广泛用于害虫控制.
- 农药残留物和直接应用对牲畜和家禽健康构成风险,特别是影响免疫系统.
- 了解fipronil对家禽免疫力的毒理影响对于畜牧业和食品安全至关重要.
研究的目的:
- 为了评估fipronil对家禽鸟类免疫系统的毒理病学影响.
- 评估不同的fipronil剂量对免疫学参数和淋巴细胞器官组织学的影响.
主要方法:
- 100只一天大的小被分为五组 (对照组和四组治疗组).
- 菲普罗尼尔是口服的,剂量为1.5,2.5,3.5和4.5毫克/公斤.
- 免疫学参数 (抗体标位,细胞活性,鸟类结核素反应) 和淋巴细胞器官的组织病理在第15,30和45天被评估.
主要成果:
- 菲普罗尼尔的使用导致了对纽卡斯尔病病毒 (NDV) 和绵羊红细胞 (SRBC) 的抗体标位的降低.
- 在接受菲普罗尼尔治疗的组中观察到细胞活性降低和禽类结核素敏感性受损.
- 组织病理学检查显示,对Fabricius的囊,胸腺和脏有毒影响.
结论:
- 暴露于菲普罗尼尔显著损害了家禽鸟类的免疫系统.
- 该研究表明,fipronil具有免疫抑制作用,影响幽默性和细胞介导免疫力.
- 即使fipronil的亚致死的剂量也可能导致关键淋巴细胞器官的有害本病学变化.
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