治疗 sciatica 的脊柱操纵与与阿片类药物有关的不良事件之间的关联:一项回顾性队列研究
Robert J Trager1,2,3, Zachary A Cupler4,5, Roshini Srinivasan1,6
1Connor Whole Health, University Hospitals Cleveland Medical Center, Cleveland, Ohio, United States of America.
PloS one
|January 28, 2025
概括
脊椎治疗 (CSM) 对于 sciatica 患者,与常规护理相比,显著减少了 71% 的与阿片类药物相关的不良药物事件 (ORADEs). 这表明CSM是一种有价值的非阿片类药物选择,用于管理 sciatica 疼痛并预防不良结果.
科学领域:
- 综合医学是一个整体的医学.
- 疼痛管理 疼痛管理
- 药物监督 药物监督 药物监督
背景情况:
- 脊柱脊柱操纵 (CSM) 与脊柱疼痛患者的阿片类药物处方减少和不良药物事件有关.
- 有证据表明,CSM可能会降低药物不良事件的风险.
研究的目的:
- 调查假设,接受CSM的坐骨神经炎的成年人有降低了与阿片类药物相关的不良药物事件 (ORADEs) 的风险.
- 在一年的随访期间,将接受CSM治疗的坐骨神经炎患者的ORADEs与接受通常医疗护理的匹配对照进行比较.
主要方法:
- 美国基于索赔的数据资源 (2009-2024) 搜索了成年 sciatica 患者.
- 倾向性得分匹配创建了两个队列:CSM和通常医疗保健.
- 使用风险比率 (RRs) 分析了包括ORADEs和口服阿片类药物处方在内的比较结果.
主要成果:
- 在CSM队列中,ORADEs的发病率明显较低 (0.09%),而通常的医疗保健 (0.30%),RR 0.29.
- 在CSM患者中,ORADEs的风险降低了32% (RR 0.29;P < .00001).
- 此外,CSM患者接受口服阿片类药物处方的风险也较低 (RR 0.68;P < .00001).
结论:
- 与通常的医疗护理相比,接受CSM的 sciatica成年人表现出ORADEs的风险明显较低.
- 降低ORADEs的风险可能归因于CSM患者中阿片类药物处方的可能性较低.
- 研究结果支持现有指南,建议在必要时使用CSM来治疗坐骨神经炎.
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