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CT扫描衍生的胸肌参数与COVID-19结果密切相关:系统性审查和元分析

Zhang Wen¹, Tao Wang², Sha Luo¹

¹Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, China.

|January 28, 2025

概括

在COVID-19患者中,胸部肌肉密度 (PMD) 较高与较低的死亡风险相关. 更高的胸部肌肉指数 (PMI) 与减少输管率有关,这表明CT扫描肌肉参数是有价值的预后工具.

科学领域:

放射学放射学是一门学科.
肺部病理学肺部病理学
临界护理医学临界护理医学

背景情况:

在COVID-19患者中胸部肌肉特征的预后意义尚未得到充分确立.
了解这些关系可以帮助患者管理和预测结果.

研究的目的:

系统地评估胸部肌肉参数与COVID-19患者的临床结果之间的关联.
为了确定胸部CT衍生的肌肉指标是否可以作为预后指标.

主要方法:

从2019年1月到2024年5月,在主要数据库 (PubMed,Embase,Web of Science,Cochrane Library) 中进行了全面的文献搜索.
对9项涉及4109名COVID-19患者的研究数据进行了元分析 (随机效应和固定效应模型).
研究偏差使用纽卡斯尔-太华尺度进行评估,异质性用I2统计量化.

主要成果:

更高的胸部肌肉密度 (PMD) 与死亡风险降低有关 (OR = 0.95,95% CI:0.92-0.99).
较高的胸肌指数 (PMI) 与需要输内管的可能性较低相关 (OR = 0.96,95% CI:0.92-1.00).

结论:

低PMD表明COVID-19患者的死亡风险略有增加.
降低PMI是输入管的风险因素,突出了胸部CT扫描上胸部肌肉参数的预后效用.

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