肠道微生物群作为高尿血症的新目标:从天然植物产品的角度来看
Ling Dong1, Fengying Dong1, Pingping Guo1
1School of Life Sciences and Medicine, Shandong University of Technology, Zibo, Shandong, 255000, China.
概括
植物性天然产品通过调节肠道微生物群,为管理高尿素血症提供了一个新的策略. 这种方法针对尿酸水平并减少炎症,为传统药物提供更安全的替代品.
科学领域:
- 代谢障碍 代谢障碍 代谢障碍
- 肠道微生物组研究研究
- 自然产品化学 自然产品化学
背景情况:
- 超尿血,与纯素代谢障碍相关,提高血清尿酸 (UA).
- 慢性高尿血症可能导致痛风和损伤.
- 目前的UA降低药物具有显著的毒性副作用,需要新的治疗点.
研究的目的:
- 通过肠道微生物群调节,审查最近在预防和治疗高尿路血症方面的进展.
- 探索植物衍生天然产品在管理与肠道微生物群相关的高尿路血症方面的机制.
主要方法:
- 从PubMed,科学网,科学直播和CNKI (2020年1月至2024年12月) 系统审查文献.
- 根据PRISMA指南进行数据检索和分析.
- 在超尿血症治疗中涉及自然产品和肠道微生物群的机制的分类和总结.
主要成果:
- 肠道微生物群调节可以通过增强的 purin 降解,减少 UA 生产和增加 UA 排泄来降低宿主 UA 水平.
- 肠道微生物群表现出抗炎和抗氧化性质,减轻高尿血症引起的损伤.
- 植物性天然产品,其多组分协同作用和最小的副作用,有效调节肠道微生物群,用于治疗高尿血症.
结论:
- 植物性天然产品通过调节肠道微生物群,在预防和治疗高尿素血症及其并发症方面表现有前途.
- 这一审查为开发更安全,更有效的UA降低产品提供了新的视角.
- 用天然产品向肠道微生物群代表了高尿血症治疗的新前沿.
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