在结直肠癌的新辅助疗法后,磁共振完整反应的预测值
Charles Liu1, Ana Carolina A Boncompagni2, Kenneth H Perrone3
1Section of Colorectal Surgery, Division of General Surgery, University of Washington School of Medicine, Seattle, Washington.
The Journal of surgical research
|January 28, 2025
概括
磁共振完全响应 (mrCR) 在预测直肠癌新辅助治疗后病理完全响应 (pCR) 的准确性较低. 在非操作性管理决策中使用mrCR时建议谨慎使用.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 胃肠病学 胃肠病学
背景情况:
- 对直肠癌的新辅助疗法旨在改善结果.
- 对非操作性管理的兴趣正在增加,对于有利的响应者来说.
- 准确预测病理完整反应 (pCR) 对于非手术管理至关重要.
研究的目的:
- 评估当前磁共振完全响应 (mrCR) 和pCR在局部晚期直肠癌中的相关性.
- 在新辅助疗法后,确定mrCR对pCR的预测值.
主要方法:
- 对直肠腺癌患者的回顾性队列研究.
- 患者接受了新辅助化学辐射,随后进行了分泌切除术.
- mrCR和pCR是主要的终点,由MRI和病理学分别定义.
主要成果:
- 包括157名患者;8.9%的人获得了mrCR,7.0%的人获得了pCR.
- 对于pCR的mrCR的灵敏度为36.4%,正预测值为28.6%.
- 调查结果在研究期间 (2012-2021) 保持一致.
结论:
- 在局部晚期直肠癌中,mrCR对pCR的预测值较低.
- 在讨论非操作性管理时,应该谨慎使用mrCR.
- 对于那些选择在mrCR后进行非手术治疗的患者来说,频繁的监测至关重要.
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