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报告的青素过敏的全球流行:系统性审查和元分析

Akish Luintel¹, Joseph Healy², Michael Blank²

¹Institute of Global Health Innovation, Imperial College London, UK.

The Journal of infection

|January 28, 2025

概括

在全球范围内,9.4%的成年人被标记为青素过敏 (PenA),这种情况往往被误诊. 这种患病率因国家收入而异,显着需要更广泛的数据收集以支持青素取消标签的倡议.

科学领域:

临床医学临床医学
传染性疾病传染性疾病
公共卫生公共卫生

背景情况:

青素过敏 (PenA) 标签导致广泛使用抗生素,增加抗菌素耐药性和不良结果.
大约95%的带有PenA标签的患者可能被误诊.
青素取消标签的计划正在出现,但目前范围有限.

研究的目的:

为了确定青素过敏 (PenA) 标签的全球患病率.
为全世界的青素取消标签计划的潜在影响和范围提供信息.

主要方法:

成年人PenA患病率研究的系统审查和元分析.
纳入标准:2003年1月至2023年6月期间发表的研究.
提取的数据:PenA流行率,过敏记录方法,医疗保健环境,国家收入.

主要成果:

分析了来自28个国家的174项研究,包括18352名患者.
全球PenA流行率为9.4% (95%CI为8.4-10.4%).
与中等收入国家 (MIC) (4.4%) 相比,高收入国家 (HIC) 报告了更高的PenA患病率 (9.9%).
研究很大程度上倾向于HICs (92%) 和二级护理机构.
过敏记录方法对报告的患病率产生了重大影响.

结论:

PenA患病率数据集中在HIC和二级护理中,非洲,亚洲和南美洲的代表性有限.
在全球代表性不足的地区急需扩大流行病学研究.
解决数据缺口对于有效的全球性青素取消标签策略至关重要.

关键词:

抗菌药物反症 (AMR) 是一种美国航空航天管理系统 (AMS)抗生素耐药性抗生素耐药性抗微生物耐药性抗微生物耐药性抗微生物药物管理管理对于β-乳酸过敏的反应药物过敏药物过敏药物过敏青素过敏青素过敏世卫组织的政策政策.

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