阿比拉酸盐固定剂量组合与以布洛芬为基础的治疗性浸泡和深浸泡溶剂
Shaida Panbachi1, Josef Beranek2, Martin Kuentz3
1University of Basel, Department of Pharmaceutical Sciences, Klingelbergstrasse 50, 4056 Basel, Switzerland; Zentiva, k.s., U Kabelovny 130, 102 00 Praha 10, Czech Republic; University of Applied Sciences and Arts Northwest. Switzerland, School of Life Sciences, Institute of Pharma Technology, Hofackerstr. 30, CH-4132 Muttenz, Switzerland.
这项研究开发了新型基于药物的治疗性深度浸泡溶剂 (THEDESs),使用布洛芬来增强固剂组合抗癌疗法中阿比拉酸盐的溶解性.
科学领域:
- 制药科学 制药科学
- 材料科学 材料科学 材料科学
- 计算化学的计算化学
背景情况:
- 难以溶解的药物对口服药物的配方构成了挑战.
- 深度浸泡溶剂 (DES) 显示出增强药物溶解性的潜力.
- 治疗性DES (THEDES) 通过结合治疗剂提供了一种双重作用的方法.
研究的目的:
- 探索基于布洛芬 (IBU) 的治疗性深度浸泡溶剂 (THEDESs) 溶解阿比拉酸盐 (AbAc) 的潜力.
- 创建IBU和AbAc的固定剂量组合配方,增强溶解性和溶解性.
- 研究脂肪酸链长度对基于IBU的THEDESs溶解能力的影响.
主要方法:
- 制备和描述四种基于IBU的THEDES,含有不同脂肪酸 (八度酸,非八度酸,十度酸,十二度酸).
- 量子化学计算以确定脂肪酸的表面电荷密度.
- 从开发的THEDES配方中进行的AbAc和IBU的体外溶解研究,有或没有Tween 80.
主要成果:
- 基于IBU的THEDES显示了AbAc的显著溶解,在IBU:OctA中最大溶解为1311.0±125.4mg/g.
- 试管溶解显示IBU和AbAc同时释放,在添加Tween 80后,百分比增加.
- 脂肪酸链长度影响了AbAc溶解,较短的链具有更高的容量.
结论:
- 基于药物的THEDES是有效的溶解可溶性较差的药物,如AbAc.
- 基于IBU的THEDES为开发固定剂量组合口服配方提供了可行的策略.
- 这些发现凸显了THEDES在药物输送和组合治疗中的潜力.
更多相关视频
08:56Synthesis of a Borylated Ibuprofen Derivative Through Suzuki Cross-Coupling and Alkene Boracarboxylation Reactions
Published on: November 30, 2022
10:38Establishing 3-Dimensional Spheroids from Patient-Derived Tumor Samples and Evaluating their Sensitivity to Drugs
Published on: December 16, 2022
相关概念视频
Dosage Regimen: Fixed Dose
Fixed-dose regimens can be used for various routes of administration, including intravenous (IV) injections and oral medications. For IV administration, a predetermined amount of the drug is...
Drugs for Treatment of Diarrhea-Predominant IBS
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
Combined Effects of Drugs: Synergism
Such synergistic combinations...
Combination Therapies and Personalized Medicine
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...
