大脑肠道微生物群网络 (BGMN) 与精神分裂症患者的症状严重程度和神经认知相关
Runlin Peng1, Wei Wang1, Liqin Liang1
1School of Biomedical Sciences and Engineering, South China University of Technology, Guangzhou International Campus, Guangzhou 511442, China.
研究人员开发了一种新的方法来将精神分裂症 (SZ) 中的大脑和肠道微生物联系起来. 这种脑-肠-微生物群轴分析准确地区分了SZ患者,并确定了与大脑网络和认知功能相关的特定微生物.
科学领域:
- 神经科学是一个神经科学.
- 微生物学 微生物学
- 精神病学是一个精神病学.
背景情况:
- 大脑-肠-微生物群轴在精神分裂症 (SZ) 神经病理学中发挥着作用.
- 在SZ中,肠道微生物群和大脑功能之间的特定关联模式尚不清楚.
- 了解这些联系对于诊断和治疗SZ至关重要.
研究的目的:
- 研究SZ患者的大脑特征和肠道微生物群之间的关联模式.
- 开发一种用于构建个体脑肠微生物群网络 (BGMNs) 的新方法.
- 为了将BGMN特征与SZ的症状严重程度和神经认知相关联.
主要方法:
- 获得了休息状态功能磁共振成像 (rs-fMRI) 和来自43名SZ患者和55名正常对照者的肠道微生物群数据.
- 从rs-fMRI中计算的大脑特征和从微生物群数据中计算肠道特征.
- 通过整合大脑和肠道特征构建了个别的BGMNs,并构建了歧视模型.
主要成果:
- 综合的BGMN模型在区分SZ患者和NC患者方面实现了0.90准确度和0.97AUC.
- 关键的区分特征涉及Faecalibacterium和Collinsella属,与特定的大脑区域和网络相关.
- 一些歧视性特征与SZ患者的神经认知评分有显著的相关性.
结论:
- 新的BGMN构建方法有效地揭示了SZ中的脑肠微生物群协会.
- 这种方法有助于理解精神分裂症的神经病理学.
- 已识别的微生物特征为SZ提供了潜在的生物标志物.
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