基于科塔杜提德可逆自组装的长效注射储存器,用于持续输送GLP-1葡萄糖受体激活剂,并控制突发释放

Bin Yang1, Durga Devalla1, Silvia Sonzini1

  • 1Advanced Drug Delivery, Pharmaceutical Sciences, R&D, AstraZeneca, Biomedical Campus, Cambridge, UK.

概括

这项研究开发了一种新型的长效注射配方,用于双GLP-1 / 葡萄糖受体激动剂cotadutide. 在聚合物仓库中封装codatutide纤维显著延长了其半衰期,使每月剂量用于代谢疾病.

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