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口服吸收的植物微RNA的特征和功能
Yating Zhu1, Yicheng Yu2, Yao Jia1
1Evidence-Based Medicine Research Center, Jiangxi University of Chinese Medicine, Nanchang City, Jiangxi Province, P. R. China.
Planta medica
|January 28, 2025
概括
来自草药的植物微RNA可以被吸收并调节人类的基因. 具体特征如更高的表达和更大的最小自由能量增加吸收,MIR-6240-3p显示对HCoV-229E的抗病毒作用.
科学领域:
- 药理学 药理学是指药理学的学科.
- 分子生物学分子生物学
- 遗传学 是一个遗传学.
背景情况:
- 草药中含有植物微RNA (miRNA),可以口服吸收并影响宿主基因表达.
- 了解哪些植物miRNA被吸收对于它们的治疗潜力至关重要.
研究的目的:
- 来研究两种抗病毒草药中口服吸收的植物miRNA的特征.
- 识别被吸收的特定植物miRNA并评估它们的抗病毒活性.
主要方法:
- 分别给人类志愿者和老鼠使用青飞派杜和青瑞华希康杜.
- 小RNA测序用于识别和量化吸收的植物miRNAs.
- 在体外评估MIR-6240-3p对人类冠状病毒229E型 (HCoV-229E) 的抗病毒作用.
主要成果:
- MIR-6240-3p被确定为人类口服吸收的植物miRNA,在Qingfei Paidu中高度表达.
- 可吸收的植物小RNA表现出更高的表达水平,更高的最小自由能量和更高的AU/UA频率.
- 在体外,MIR-6240-3p显著降低了HCoV-229ERNA拷贝数和感染力.
结论:
- 植物小RNA具有更高的表达,更高的最小自由能量和更高的AU/UA频率,更有可能从草药中口服吸收.
- 吸收的植物miRNAs,如MIR-6240-3p,有可能调节跨王国基因调节并产生抗病毒作用.
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