饮食中的蛋白质摄入量和PM2.5对卵巢癌存活率:一个前性队列研究
He-Li Xu1, Yi-Fan Wei1, Qi Bao2
1Department of Clinical Epidemiology, Shengjing Hospital of China Medical University, Shenyang, China; Clinical Research Center, Shengjing Hospital of China Medical University, Shenyang, China; Key Laboratory of Precision Medical Research on Major Chronic Disease, Shengjing Hospital of China Medical University, Shenyang, China.
Ecotoxicology and environmental safety
|January 28, 2025
概括
饮食中摄入的蛋白质,特别是来自鱼类,蛋和水果/蔬菜的蛋白质,可能会降低与颗粒物2.5 (PM2.5) 暴露相关的卵巢癌死亡风险. 这种互动凸显了饮食在减轻空气污染方面的重要性.
科学领域:
- 流行病学 流行病学
- 环境健康 环境健康
- 营养科学 营养科学
背景情况:
- 新出现的证据表明,饮食中的蛋白质摄入量和低于2.5微米 (PM2.5) 的颗粒物暴露与卵巢癌 (OC) 死亡率之间存在联系.
- 没有先前的流行病学研究研究了饮食蛋白和PM2.5之间与OC存活相关的相互作用.
研究的目的:
- 调查饮食中的蛋白质摄入量,PM2.5暴露和它们对卵巢癌患者生存的综合影响之间的关联.
- 探索饮食蛋白质和PM2.5之间对OC死亡率的潜在添加和乘法相互作用.
主要方法:
- 一项前性队列研究包括在中国新诊断的658名OC患者.
- 使用食物频率问卷评估了饮食中的蛋白质摄入量,使用卫星数据估计了PM2.5暴露.
- 考克斯的比例危险模型用于计算危险比率 (HRs) 和95%置信区间 (CI),并对共变量进行调整. 使用RERI和交叉产品术语来评估相互作用.
主要成果:
- 较高的鱼类,蛋和水果/蔬菜蛋白摄入量与OC患者全因死亡率的降低有关 (HRs <1,P趋势<0.05).
- 暴露于PM2.5与全因死亡率 (HR=1.52每次IQR增加) 有积极关联.
- 观察到相互作用:较低的鱼类,蛋和水果/蔬菜蛋白摄入量放大了与PM2.5暴露相关的死亡风险 (所有P的相互作用<0.05).
结论:
- 这项研究提供了饮食蛋白 (鱼,蛋,水果/蔬菜) 和PM2.5暴露之间的相互作用的证据,这些证据涉及卵巢癌患者因任何原因的死亡率.
- 坚持特定的富含蛋白质的饮食可能对于降低OC幸存者的PM2.5相关死亡风险至关重要.
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