氧化通过调节D1受体和BDNF通路在腹膜区域-核 accumbens多巴胺电路中发挥奖励作用
Wen-Qi Li1, Sheng-Nan Liu1, Si-Chang Yang1
1School of Chinese Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
娱乐性氧化 (N2O) 使用会通过增强大脑中多巴胺通路产生有益的效果. 这涉及D1受体和来自大脑的神经营养因子 (BDNF) 信号传输.
科学领域:
- 神经科学是一个神经科学.
- 药理学 药理学是指药理学的学科.
- 成研究 研究成研究
背景情况:
- 娱乐用氧化 (N2O) 的使用正在增加.
- 了解它的奖励机制对于公众健康至关重要.
研究的目的:
- 在小鼠中研究亚麻醉性氧化 (N2O) 的奖励作用.
- 阐明这些效应背后的神经生物学途径,包括多巴胺和BDNF信号传递.
主要方法:
- 在暴露于N2O.O.的小鼠中,有条件的位置偏好 (CPP) 范式.
- 药理学阻断多巴胺D1和D2受体在核 (NAc) 中.
- 评估腹膜区域 (VTA) 的多巴胺能神经元活动和NAc多巴胺水平.
- 研究大脑衍生神经营养因子 (BDNF) 在VTA和NAc中的表达和下游信号,包括BDNF的VTA焦点淘汰.
主要成果:
- 在CPP范式中,N2O诱导了显著的奖励行为.
- 奖励效应被D1受体对抗阻断,而不是D2对抗.
- N2O增强了VTA多巴胺活性和NAc多巴胺水平.
- 重复的N2O暴露在VTA中的BDNF和NAc中的下游介质上调.
- 阻断或抑制下游介质的VTA BDNF降低了N2O的奖励效应和VTA活动.
- 结合BDNF敲击和D1对抗,显示了N2O奖励的添加或协同抑制.
结论:
- 亚麻醉剂N2O通过VTA-NAc多巴胺通路进行介导,产生奖励作用.
- D1受体和BDNF/TrkB信号传递是N2O的奖励性质的关键组成部分.
- BDNF调节似乎在D1受体参与N2O奖励的上游起作用.
更多相关视频
06:40Combined Infusion and Stimulation with Fast-Scan Cyclic Voltammetry CIS-FSCV to Assess Ventral Tegmental Area Receptor Regulation of Phasic Dopamine
Published on: April 23, 2020
08:07Simultaneous Detection of c-Fos Activation from Mesolimbic and Mesocortical Dopamine Reward Sites Following Naive Sugar and Fat Ingestion in Rats
Published on: August 24, 2016
相关概念视频
Nitric Oxide Signaling Pathway
Drugs Acting on Autonomic Ganglia: Stimulants
Ganglionic stimulants activate NM nicotinic receptors in autonomic ganglia, falling into two categories: nicotine mimetics [e.g., lobeline, dimethylpiperazine, tetramethylammonium] and muscarinic receptor agonists [e.g., muscarine, methacholine]. The first category's action is rapid and blocked by nicotinic receptor antagonists, while the second category's action is delayed and blocked by atropine-like agents. Nicotine, an alkaloid, affects the heart rate by stimulating...
Adrenergic Neurons: Neurotransmission
Synthesis: Catecholamine synthesis requires tyrosine, which...
Adrenergic Agonists: Indirect-Acting Agents
One mechanism involves depleting stored catecholamines by displacing them from synaptic vesicles. These agents, known as "displacers," are transported into vesicles at the expense of noradrenaline. Examples include amphetamine and tyramine, which lack a catechol moiety, resulting in prolonged action, improved oral...
Neurotransmitters
Drugs Affecting Neurotransmitter Synthesis
