更大的住宅绿色与成人表观遗传衰老的减少有关
Andrey I Egorov1, Shannon M Griffin2, Jo Klein3
1Office of Research and Development, United States Environmental Protection Agency, 104 Mason Farm Rd., Chapel Hill, NC, 27514, USA. egorov.andrey@epa.gov.
Scientific reports
|January 28, 2025
概括
居住在更多的绿地附近,如树木和植被,与缓慢的生物衰老有关. 这项研究发现,住宅绿色增加与成人表观遗传衰老加速减少有关.
科学领域:
- 环境健康 环境健康
- 表观遗传学 在表观遗传学中,表观遗传学是指表观遗传学.
- 衰老研究研究 衰老研究
背景情况:
- 城市绿地被假设通过放松和减轻压力来改善健康.
- 表观遗传衰老加速 (EAA) 是生物衰老的生物标志物,可以预测发病率和死亡率.
- 了解对生物衰老的环境影响对于公共卫生至关重要.
研究的目的:
- 调查住宅绿地暴露与成年人表观遗传衰老加速 (EAA) 之间的关联.
- 为了确定住宅附近更大的绿色是否与生物衰老缓慢相关.
主要方法:
- 在北卡罗来纳州中部116名成年居民的横截面研究.
- 使用四种基于DNA甲基化的表观遗传年龄公式测量EAA.
- 通过树木覆盖,植被土地覆盖和NDVI在500米内居住的量化住宅绿地.
主要成果:
- 绿色的四分位数间范围的增加始终与EAA的减少有关.
- 在不同的绿色度指标中,EAA估计的减少时间从0.9年到1.6年不等.
- 在12个测试的绿色和EAA之间的11个关联是统计学上显著的 (p < 0.05).
结论:
- 对住宅绿色空间的更大暴露与表观遗传衰老的减缓有关.
- 这为环境在调节生物衰老过程中的作用提供了证据.
- 研究结果支持城市绿化对于促进健康老龄化的重要性.
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