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Updated: May 30, 2025

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一个LXRα突变揭示了胆固醇感应在限制代谢功能障碍相关的脂肪肝炎中的作用

Alexis T Clark1, Lillian Russo-Savage1,2, Luke A Ashton1

  • 1Department of Pharmacology, University of Virginia School of Medicine, Charlottesville, VA, USA.

Nature communications
|January 28, 2025
PubMed
概括

缺乏功能性肝X受体α (LXRα) 的突变小鼠在高脂肪饮食中迅速发展出代谢功能障碍相关的脂肪肝炎 (MASH). 恢复LXRα信号反转MASH,表明其在预防肝脏疾病中的关键作用.

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