老年人中乙烯氧化物暴露与认知功能之间的关联来自NHANES数据
Meng Sun1,2, Meng Cai3, Sisi Sun3
1Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, China.
Scientific reports
|January 28, 2025
概括
乙烯氧化物 (EO) 暴露可能对老年人的认知功能产生负面影响. 较高的EO水平与记忆和认知测试的分数较差相关,特别是延迟回忆测试.
科学领域:
- 环境健康 环境健康
- 神经科学是一个神经科学.
- 老年学是一门学科.
背景情况:
- 乙烯氧化物 (EO) 是一种具有潜在健康风险的挥发性有机化合物.
- 在老年人群中,EO暴露对认知功能的影响尚不清楚.
研究的目的:
- 调查乙烯氧化物 (EO) 暴露与老年人认知功能之间的关联.
- 为了确定EO生物标志物的较高水平是否与认知测试的表现下降相关.
主要方法:
- 使用2013-2014年NHANES调查数据进行的横截面研究 (n=471).
- 对log10转化血红蛋白EO (HbEO) 水平和认知测试成绩 (DRT,AFT,DSST) 的分析.
- 使用权重回归和限制立方线模型来评估关联,并对混因素进行调整.
主要成果:
- 在男性,非西班牙裔白人和吸烟者中观察到更高的HbEO水平.
- 随着HbEO水平的增加,DRT,AFT和DSST的认知测试得分通常会下降.
- 在HbEO水平和延迟回忆测试 (DRT) 分数之间发现了显著的负相关性,即使经过调整以考虑混因素.
结论:
- 乙烯氧化物暴露可能与美国老年人的认知能力受损有关,特别是延迟回忆.
- 需要进一步的研究来了解EO对认知衰老的机制和长期影响.
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