拉普丁是一种睡眠诱导的下丘脑激素,抑制食欲和肥胖
Ling-Qi Xie1, Biao Hu1, Ren-Bin Lu1
1Department of Endocrinology, Endocrinology Research Center, Xiangya Hospital of Central South University, Changsha, Hunan, China.
Cell research
|January 28, 2025
概括
一种新发现的激素Raptin在睡眠期间释放出来,通过抑制食欲,有助于预防肥胖. 睡眠不足会扰乱Raptin的释放,导致体重增加和相关疾病.
科学领域:
- 神经内分泌学神经内分泌学
- 代谢调节 代谢调节 代谢调节
- 睡眠科学 睡眠科学
背景情况:
- 睡眠不足与肥胖有关,但潜在的生物机制尚未完全理解.
- 识别参与食欲调节和能量平衡的新型荷尔蒙通路对于理解肥胖至关重要.
研究的目的:
- 为了识别和描述一种新的睡眠诱导激素,调节肥胖.
- 阐明这种激素影响食欲和胃功能的分子机制.
主要方法:
- 在人类和小鼠中识别了一种新型蛋白质激素 (Raptin),该激素是从视网素-2 (RCN2) 中分离出来的.
- 对调节拉普丁释放的神经回路的研究,涉及上神经核和副腹腔核.
- 分析拉普丁与谷氨酸甲基增生受体3 (GRM3) 和其下游信号通路 (PI3K-AKT) 的结合.
- 在睡眠不足患者和RCN2变异个体中进行的临床相关性研究.
主要成果:
- 确定了一种诱导睡眠的下丘脑激素Raptin,它来自RCN2并抑制肥胖.
- 拉普丁水平在睡眠期间达到峰值,在睡眠不足的情况下降低.
- 拉普丁通过在下丘脑和胃分别与GRM3结合来抑制食欲和胃排空.
- 由于睡眠不足而导致的Raptin释放受损与患者的肥胖有关.
- RCN2的一个无意义变体与人类的夜间饮食综合征和肥胖症有关.
结论:
- 拉普丁是一种新型激素,可以抑制食物摄入并预防肥胖,其释放受到睡眠的调节.
- 睡眠-拉普丁-食欲轴的干扰有助于肥胖和相关的代谢障碍.
- 准Raptin通路可能为管理肥胖和睡眠相关饮食障碍提供新的治疗策略.
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