前列腺癌的流行病学,诊断和治疗
Sammy Gharbieh1, Joshua Mullin1, Ata Jaffer1
1Department of Urology, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Nature reviews. Urology
|January 28, 2025
概括
前列腺癌 (APC) 经常被标准活检遗漏. 结合MRI向和系统活检,可以改善这些具有挑战性的前列腺癌的检测和手术规划.
科学领域:
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
背景情况:
- 前列腺癌 (APC) 是位于尿道前部的不可触摸的瘤.
- 传统的活检方案往往低于这些区域的样本,导致低检测率和高假阴性.
- 据估计,根据激进前列腺切除系列,APC的患病率为10-30%.
研究的目的:
- 对前列腺癌的综合MRI向和系统活检技术的诊断疗效进行评估.
- 评估APC检测对手术前工作和手术规划的影响.
- 探索MRI向技术的潜力,用于APC的焦点治疗.
主要方法:
- 针对APC患病率的激进前列腺切除系列的审查.
- 跨关节系统活检与联合MRI向和系统活检的比较.
- 活检技术与最终组织病理学之间的一致性分析.
- 评估APC特征,包括癌症体积,边缘状态和前列腺外延伸.
主要成果:
- 综合MRI向和系统活检显示高一致性与最终的组织病理学.
- 这些结合的技术将激进前列腺切除术的升级和升级降到最低.
- 与后部前列腺癌相比,APC与更大的癌症体积和更高的阳性手术利率有关.
- 前部瘤显示出更低的前列腺外延伸率,精液囊泡入侵率和淋巴结转移率.
结论:
- 结合活检技术对于前列腺癌的准确诊断和手术规划至关重要.
- 针对MRI的方法在焦点前部治疗中提供了实时手术内指导的潜力.
- 前列腺癌的前部位置可能与对疾病进展的相对抵抗性有关.
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