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在食道切除术后与门性泄漏相关的生物标志物:系统性审查

Călin Popa¹, Diana Schlanger², Alberto Aiolfi³

¹University of Medicine and Pharmacy Iuliu Hatieganu Cluj-Napoca, Regional Institute of Gastroenterology and Hepatology O. Fodor Cluj-Napoca, Croitorilor 19-21, 400162, Cluj-Napoca-Napoca, Romania.

Langenbeck's archives of surgery

|January 28, 2025

概括

系统性炎症生物标志物显示出在食道切除术后预测门性泄漏 (AL) 的潜力. 术后生物标志物,特别是术后3-5天之间的生物标志物,似乎对风险分层最有意义.

科学领域:

手术瘤学手术瘤学
胃肠病学胃肠病学
免疫学免疫学免疫学

背景情况:

肠道泄漏 (AL) 是上部胃肠道手术,特别是食道切除手术后的一种严重并发症,报告的发泄率为20-30%.
系统性炎症生物标志物对AL的预测价值仍然存在争议,需要进行系统性评估.

研究的目的:

系统地审查有关免疫-炎症因子在预测食道切除术后道泄漏中的作用的现有文献.
综合当前关于系统性炎症生物标志物对AL风险分层的有用性的证据.

主要方法:

根据PRISMA指南进行了系统审查.
在PubMed,Scopus和Embase中使用相关的MESH术语和关键词进行了搜索.
确定并分析了研究针对AL预测的免疫炎症因素的研究.

主要成果:

包括24项涉及5903名患者的研究.
研究涵盖了各种食管切除技术,主要包括接受新辅助治疗的患者.
术后生物标志物,特别是术后第3至第5天测量的生物标志物,在预测AL方面具有统计学意义.

结论:

系统性炎症生物标志物显示为风险分层和预测AL食道后手术的工具.
需要进一步的研究来验证这些生物标志物的临床实用性,以控制AL.

关键词:

解剖器的泄漏情况生物标志物生物标志物消化管外科手术是一种消化管手术.消化管切除术是指消化管切除术.

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