儿科埃索诺菲尔带炎:与成人形式的相似之处和差异
Thibaut César1, Diane Giovannini2,3, Alban Deroux4
1Department of Pediatrics, Grenoble-Alpes University Hospital, Grenoble, France.
European journal of pediatrics
|January 28, 2025
概括
儿科埃索诺菲尔性纤维炎很少见,但这项研究发现了与成人形式的关键差异,包括关节收缩和更频繁的高甘球蛋白血症. 治疗通常涉及物理治疗,皮质类固醇和甲醇.
科学领域:
- 儿科风湿病学 儿科风湿病学
- 皮肤病学 皮肤病学
- 病理学 病理学 病理学
背景情况:
- 酸性膜炎是一种极其罕见的疾病,特别是在儿科患者群体中,关于其特定特征的数据有限.
- 以前的报道表明了潜在的儿科特异性特征,需要进一步调查.
研究的目的:
- 识别儿科埃索诺菲尔性粘膜炎病例并描述其临床,准临床和治疗特征.
- 为了比较儿科埃索诺菲尔带炎的表现和管理与成人形式.
主要方法:
- 通过法国和周边国家的儿科风湿病学学会发出了征求意见的呼吁.
- 收集和分析了2004年至2022年间被诊断为患有乙性带炎的八名儿科患者的临床和准临床数据.
- 诊断工具包括MRI和全厚生检.
主要成果:
- 八名儿科患者 (平均年龄8.7岁) 呈现了皮肤和关节的卷入.
- 在5/8的患者中观察到埃索因过敏症,在5/7.的患者中观察到高甲基球蛋白血症.
- 在6名患者中,MRI揭示了T2超信号加厚的带膜;活检显示了所有患者的特征性炎症,在4名患者中呈现了eosinophils.
结论:
- 这项研究代表了迄今为止最大的儿科系列埃索诺菲尔性粘膜炎.
- 儿科埃索诺菲尔带炎与成年形式有相似之处,但可能会出现孤立的关节收缩和更频繁的高甘球蛋白血症.
- 诊断依赖于皮肤学和病理学专业知识,以及MRI发现.
- 双方同意的第一线治疗包括物理治疗,长期的皮质类固醇治疗和甲醇.
相关概念视频
01:26Asthma-II: Pathophysiology and Classification
2.6K
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
2.6K
01:20Asthma: Pathogenesis and Management
343
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
343
01:25Ultrasound II: Endoscopic Ultrasound and FibroScan
74
Endoscopic Ultrasound (EUS) and FibroScan are valuable diagnostic tools in gastroenterology and hepatology, each with specific applications and techniques.
Endoscopic Ultrasound (EUS):
Endoscopic Ultrasound (EUS):
74
01:22Role of Ephrin-Eph Signalling in Intestinal Stem Cell Renewal
2.2K
Erythropoietin-producing hepatocellular carcinoma receptor (Eph) and its ligand, Eph receptor-interacting protein (Ephrin) were first discovered in the human carcinoma cell line, hence the name. Ephrin-Eph interaction guides cells to reach their appropriate location in adult tissues. They also play an essential role in the immune system by helping in immune cell migration, adhesion, and activation. Based on their structure and function, Eph is divided into two classes — EphA and EphB.
2.2K
01:29Gastroesophageal Reflux Disease II: Clinical Features and Management
51
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
51
01:23Skin Diseases and Disorders
2.8K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
2.8K