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常见和明显的神经模式的灰色物质变化在成年人有精神性厌食症和强迫症
Xinyue Wan1,2, Pengfei Zhang3, Yanli Jiang4,5
1Department of Radiology, Huashan Hospital, State Key Laboratory of Medical Neurobiology, Fudan University, Shanghai, China.
European archives of psychiatry and clinical neuroscience
|January 28, 2025
概括
神经性厌食症 (AN) 和强迫症 (OCD) 在特定的大脑区域共享重叠的灰质体积减少,包括胰岛,上回,罗兰 operculum 和下额头回.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 放射学 放射学是一门学科.
背景情况:
- 神经性厌食症 (AN) 和强迫症 (OCD) 呈现出显著的症状重叠和高的并发症.
- 人们对AN和强迫症之间潜在的神经解剖学差异和相似之处的理解尚不完全.
研究的目的:
- 为了识别与健康对照者相比,AN和OCD患者的重叠和明显的灰质体积 (GMV) 变化.
- 阐明AN和强迫症共享症状和并发症的共同神经生物学基础.
主要方法:
- 使用基于种子的d绘图与对象图像工具箱 (SDM-PSI) 软件进行了对GMV的voxel-wise元分析.
- 在AN患者,强迫症患者和健康对照者之间比较GMV.
主要成果:
- AN患者在补充运动区域,中间环状皮层,左小脑,右罗兰 operculum (RO),右岛,右上旋 (STG) 和右前肌中显示出减少的GMV.
- 强迫症患者在右侧胰岛,STG,RO和下额头 (IFG) 中表现出减少的GMV.
- 结合分析显示,在AN和强迫症患者中,右侧胰岛,STG,RO和IFG的GMV减少重叠. 没有发现任何明显的GMV变异.
结论:
- 这些发现表明,在特定的皮层和皮下区域共享的结构性大脑异常可能导致类似的神经心理特征和在AN和OCD中观察到的高并发症.
- 这些常见的神经解剖学缺陷为未来研究神经病理学和这些疾病的治疗提供了潜在的目标.
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