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相关概念视频

Protein Organization01:24

Protein Organization

6.2K
Proteins are polymers of amino acid residues. They are versatile and responsible for different cellular functions, including DNA replication, molecular transport, catalysis, and structural support. Proteins have a hierarchical structure comprising at least three levels of organization: primary, secondary, and tertiary structure. Some large proteins have a quaternary structure where individual protein subunits are linked together.
The primary structure of a protein is its amino acid sequence....
6.2K
Protein and Protein Structures02:15

Protein and Protein Structures

10.3K
10.3K
Protein and Protein Structure02:15

Protein and Protein Structure

78.1K
Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme...
78.1K
Protein Families02:47

Protein Families

15.2K
Protein families are groups of homologous proteins; that is, they have similarities in amino acid sequences and three-dimensional structures. Protein families usually occur because of gene duplication, where an additional copy of a gene is inserted into the genome of an organism.   Mutations that change the amino acids but still allow the protein to be properly synthesized, will lead to new protein family members.   If these new proteins contain similar amino acids in key...
15.2K
Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

10.8K
Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
A limited set of protein domains often duplicate and recombine during evolution. These domains can be organized in different combinations to...
10.8K
Globular and Fibrous Proteins02:21

Globular and Fibrous Proteins

43.3K
Many proteins can be classified into two distinct subtypes - globular or fibrous. These two types differ in their shapes and solubilities.
Globular proteins are also known as spheroproteins and typically are approximately round in shape. They contain a mix of amino acid types and contain differing sequences in their primary structures. Globular proteins have many different functions, such as enzymes, cellular messengers, and molecular transporters. These roles often require the proteins to be...
43.3K

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相关实验视频

Updated: May 30, 2025

Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web
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Investigating Protein Sequence-structure-dynamics Relationships with Bio3D-web

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PSSKB:一个用于研究蛋白质结构的Web应用程序.

Denis V Petrovskiy1, Kirill S Nikolsky1, Liudmila I Kulikova1

  • 1Laboratory of Structural Proteomics, Institute of Biomedical Chemistry, Pogodinskaya, Moscow, Russia.

Journal of computational chemistry
|January 29, 2025
PubMed
概括
此摘要是机器生成的。

PSSKB是一个用于建模蛋白质翻译后修饰 (PTM) 和氨基酸替代 (AAS) 的新平台. 它提供3D结构分析和相似性搜索,以了解蛋白质的功能和变化.

关键词:
三维结构的3D结构.在 PSSKB 平台平台上.在 PTM 建模中.氨基酸替代服务 氨基酸替代服务生物信息学是一种生物信息学.

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A Protocol for Computer-Based Protein Structure and Function Prediction
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A Protocol for Computer-Based Protein Structure and Function Prediction

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An Integrated Approach for Microprotein Identification and Sequence Analysis
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An Integrated Approach for Microprotein Identification and Sequence Analysis

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相关实验视频

Last Updated: May 30, 2025

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科学领域:

  • 结构生物学是结构生物学.
  • 生物物理学的生物物理.
  • 生物信息学是一种生物信息学.
  • 计算生物学是一种计算生物学.

背景情况:

  • 细胞周期蛋白对于细胞功能和信号传递至关重要.
  • 了解从翻译后修饰 (PTM) 和氨基酸替代 (AAS) 中产生的蛋白质结构变化对于理解蛋白质功能,稳定性和局部化至关重要.
  • 现有的工具往往缺乏用于全面PTM和AAS分析的综合功能.

研究的目的:

  • 引入蛋白质结构和稳定性知识库 (PSSKB),这是一个用于建模和分析蛋白质修饰的综合平台.
  • 为可视化和评估PTM和AAS对蛋白质结构和性能的影响提供工具.
  • 提供蛋白质结构相似性搜索功能.

主要方法:

  • PSSKB集成了用于建模五种常见的自然PTM和所有正规AAS的工具.
  • 用户可以通过UniProt ID或PDB ID输入蛋白质数据.
  • 该平台对完整和修改结构进行能源最小化,以分析性能变化.
  • 使用先前开发的软件 (SaFoldNet) 进行结构图案相似性搜索.

主要成果:

  • PSSKB生成了修改的蛋白质结构的3D表示.
  • 它提供了对AAS和PTM如何影响蛋白质特性的定量分析.
  • 该平台有助于搜索,对齐和叠加蛋白质结构片段,返回统计学上排名的类似图案.
  • 该平台是公开可访问的,无需注册.

结论:

  • PSSKB提供了一个全面的,用户友好的解决方案,用于研究PTM和AAS在蛋白质中的结构和功能后果.
  • 该平台帮助研究人员评估蛋白质的行为,并利用3D模型进行进一步的研究.
  • 通过集成的建模和搜索工具,PSSKB增强了蛋白质结构分析和发现.