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相关概念视频

Theories of Dissolution: Diffusion Layer Model01:15

Theories of Dissolution: Diffusion Layer Model

Dissolution, the process by which drug particles dissolve in a solvent, is explained by the diffusion layer model, a theoretical framework that simulates the absorption of oral drugs and allows us to analyze experimental data.
This process starts with a thin layer, saturated with the drug, forming at the interface between the solid and liquid. The solute then diffuses from this layer into the main solution. The Noyes-Whitney equation suggests that the rate of dissolution relies on the diffusion...
In Vitro Drug Dissolution: Compendial Testing Models I01:13

In Vitro Drug Dissolution: Compendial Testing Models I

Compendial dissolution methods are standardized procedures defined by pharmacopeias to evaluate the rate at which a drug dissolves in a specific medium. These methods ensure batch-to-batch consistency, enable quality control, and support the prediction of drug bioavailability. They are critical for both immediate and modified-release drug products.The apparatuses used for dissolution testing differ in their design and mechanical function, but all aim to simulate the physiological environment of...
In Vitro Drug Dissolution: Compendial Testing Models II01:09

In Vitro Drug Dissolution: Compendial Testing Models II

Various dissolution methods are utilized to assess a drug’s dissolution rate, including the flow-through cell, paddle-over-disk, cylinder, and reciprocating disk methods.The flow-through cell apparatus (USP (United States Pharmacopeia) method 4) comprises a reservoir for the dissolution medium and a pump that propels the medium through the cell containing the test sample. This method is crucial for assessing modified-release dosage forms with minimally soluble active ingredients, maintaining...
In Vitro Drug Dissolution: Alternative Methods01:17

In Vitro Drug Dissolution: Alternative Methods

Alternative drug dissolution methods include the rotating bottle, intrinsic dissolution test, peristalsis, and the Franz diffusion cell method. The rotating bottle method involves meticulously rotating tightly capped controlled-release beads in a temperature-controlled bath. Periodic decanting of samples allows for residue assay, followed by refilling with fresh medium and testing at various pH levels to emulate the gastrointestinal tract conditions.In contrast, the intrinsic dissolution test...

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Controlled Synthesis and Fluorescence Tracking of Highly Uniform PolyN-isopropylacrylamide Microgels
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溶解/扩散过程多参数同时测量的光学方法,基于液芯圆柱状透镜.

Rui Zeng, Zhiwei Li, Danyang Wang

    Optics express
    |January 29, 2025
    PubMed
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    此摘要是机器生成的。

    本研究提出了一种新的光学方法,可以同时测量固体在液体中的溶解速率,溶解速率常数和扩散系数. 这种技术为各种行业的关键参数测量提供了更快,更直观的方法.

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    科学领域:

    • 物理化学 物理化学
    • 材料科学 材料科学 材料科学
    • 化学工程是化学工程的重要组成部分.

    背景情况:

    • 固体在液体中的溶解和扩散是具有关键参数的基本过程,如溶解速率 (dC/dt),溶解速率常数 (K) 和扩散系数 (D).
    • 目前用于测量这些参数的方法往往是耗时的,间接的,不能同时确定这些参数.
    • 准确测量这些参数对于生物制药,材料科学和农业的应用至关重要.

    研究的目的:

    • 开发和验证一种新的光学方法,用于同时测量溶解速率,溶解速率常数和扩散系数.
    • 将这种方法应用于在水中溶解的二酸 (KDP) 粉末,固体和晶体形式.
    • 为现有测量技术提供更直观,更有效的替代方案.

    主要方法:

    • 使用复合液芯圆柱状镜头 (SLCL-Doublet) 与实时光学图像特征提取.
    • 与溶液度相关的溶解/扩散图像宽度,以建立动态的时空空间度分布.
    • 应用了Fick的第二定律来计算扩散系数 (D) 和Noyes-Whitney方程来计算溶解速率 (dC/dt) 和速率常数 (K).

    主要成果:

    • 在不同状态下的KDP同时成功测量了多个溶解和扩散参数.
    • 使用开发的光学方法计算了扩散系数 (D),溶解速率 (dC/dt) 和溶解速率常数 (K).
    • 通过通过Nernst-Brunner方程确定固体-液体接触面积来验证测量准确度.

    结论:

    • 开发的光学方法可以同时实时测量关键溶解和扩散参数.
    • 与传统方法相比,这种技术在效率和直观性方面提供了显著的改进.
    • 该方法在扩大化学和制药行业的基本数据方面具有广泛的应用.