根据CPAK分类,膝盖表型分布在土耳其人口中
Vahit Emre Özden1,2, Göksel Dikmen1,2, Kayahan Karaytuğ1,2
1Department of Orthopedics and Traumatology, Acibadem Mehmet Ali Aydinlar University Faculty of Medicine, Istanbul, Türkiye.
Acta orthopaedica et traumatologica turcica
|January 29, 2025
概括
这项研究使用CPAK分类分析了土耳其人膝盖表型. CPAK IV型和I型在健康膝盖和骨关节炎膝盖中最为普遍,V型是不常见的.
科学领域:
- 整形外科 整形外科 整形外科
- 放射学 放射学是一门学科.
- 生物医学工程 生物医学工程
背景情况:
- 膝盖表型影响骨关节炎的发展和治疗.
- 起重机王分类 (CPAK) 分类了膝盖形态.
- 了解不同人群中CPAK分布对于个性化医学至关重要.
研究的目的:
- 确定CPAK膝盖表型在土耳其人口中的分布.
- 为了比较健康膝盖与骨关节炎膝盖的CPAK分类.
- 评估CPAK类型V的患病率,这是机械对齐策略的目标.
主要方法:
- 对1172个非关节炎和571个骨关节炎膝盖进行放射性EOS分析.
- 膝盖被分为9个CPAK子组,基于算术-膝-脚 (aHKA) 角度和关节线斜率 (JLO).
- 使用Sectra工作站,从中间近端角 (MPTA) 和侧面远端股骨角 (LDFA) 获得的测量结果.
主要成果:
- 第四类CPAK最常见于非关节炎膝盖 (46.67%) 和第一类CPAK最常见于骨关节炎膝盖 (20.7%).
- 在非关节炎组中,CPAK型V的发病率为7.7%,在关节炎组中为8.4%.
- 在非关节炎和骨关节炎组之间观察到aHKA和JLO平均值的显著差异.
结论:
- CPAK IV型和I型是土耳其人口中占主导地位的膝盖表型.
- 相关于机械对齐的CPAK类型V,在健康的膝盖和骨关节炎膝盖中都有很低的患病率.
- 这些发现突出了膝盖形态和CPAK分布的特定人群变异.
相关概念视频
Pleiotropy
39.6K
Pleiotropy is the phenomenon in which a single gene impacts multiple, seemingly unrelated phenotypic traits. For example, defects in the SOX10 gene cause Waardenburg Syndrome Type 4, or WS4, which can cause defects in pigmentation, hearing impairments, and an absence of intestinal contractions necessary for elimination. This diversity of phenotypes results from the expression pattern of SOX10 in early embryonic and fetal development. SOX10 is found in neural crest cells that form melanocytes,...
39.6K
Polygenic Traits
64.7K
When more than one gene is responsible for a given phenotype, the trait is considered polygenic. Human height is a polygenic trait. Studies have uncovered hundreds of loci that influence height, and there are believed to be many more. Due to the high number of genes involved, as well as environmental and nutritional factors, height varies significantly within a given population. The distribution of height forms a bell-shaped curve, with relatively few individuals in the population at the...
64.7K
Pedigree Analysis
83.8K
Overview
83.8K
Genetic Lingo
100.3K
Overview
100.3K
Incomplete Dominance
21.0K
Gregor Mendel's work (1822 - 1884) was primarily focused on pea plants. Through his initial experiments, he determined that every gene in a diploid cell has two variants called alleles inherited from each parent. He suggested that amongst these two alleles, one allele is dominant in character and the other recessive. The combination of alleles determines the phenotype of a gene in an organism.
21.0K
Bones of the Lower Limb: Femur and Patella
2.1K
The femur is the body's longest and strongest bone spanning the thigh region. Its head articulates with the acetabulum of the hip bone to form the hip joint. A minor indentation on the medial side of the femoral head, called the fovea capitis, serves as the site of attachment for the ligament of the head of the femur. This weak ligament spans the femur and acetabulum and supports the hip joint. The narrowed region below the head is the neck of the femur. The inclination angle between the...
2.1K


