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脑网络成像:对部关疾病机制的洞察

R Zhao¹, Z Ye¹, X Lv¹

¹Department of Radiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.

Journal of dental research

|January 29, 2025

概括

关节障碍涉及大脑网络功能障碍,特别是注意力,情绪和疼痛调节. 神经成像揭示了默认模式,中央执行和突出网络中的改变活动,提供了潜在的治疗疗效标志物.

科学领域:

神经科学是一个神经科学.
头骨大和面部医学
精神病学是一个精神病学.

背景情况:

部部疾病 (TMD) 是一种导致疼痛和运动功能障碍的部部面部疾病.
患者经常表现出中枢神经系统功能障碍,包括情绪障碍,其根本原因不明.
三重网络模型为TMD中大脑网络改变提供了洞察力.

研究的目的:

通过神经成像来研究患有关节障碍的患者的大脑网络变化.
探索大脑网络功能障碍与疼痛和负面情绪等症状之间的关系.
评估这些网络变化作为治疗疗效的生物标志物的潜力.

主要方法:

利用神经成像技术分析大脑活动和功能连接.
专注于默认模式网络,中央执行网络和突出网络.
检查皮质缩和相关大脑区域的代谢变化.

主要成果:

在默认模式中,网络注意区域的异常激活与疼痛反有关.
皮质缩和改变了情绪和疼痛调节区域的连接性.
中央执行网络疼痛调节区域的活动减少,负面情绪区域的异常激活.
突出网络疼痛感知和情绪区域的异常激活和代谢变化.

结论:

TMD与默认模式,中央执行和突出网络的重大变化有关.
这些神经成像发现为TMD神经病理生理学提供了更深入的理解.
网络活动的变化可以作为评估TMD治疗有效性的指标.

关键词:

大脑功能大脑功能大脑功能灰色物质是一种灰色物质.磁共振成像 (MRI) 的使用.肌筋关节的疼痛肌筋关节的疼痛神经科学/神经生物学面部或面部疼痛/TMD

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