间隔的跨头直流刺激对于重大抑郁症.
Maxime Couture1, Véronique Desbeaumes Jodoin1, Emma Bousseau1
1Centre Hospitalier de l'Université de Montréal (CHUM) and Centre de Recherche du CHUM (CRCHUM), University of Montreal, Montreal (Couture, Desbeaumes Jodoin, Bousseau, Sarshoghi, Miron, Lespérance); IfADo Leibniz Research Center for Working Environment and Human Factors at TU Dortmund, Germany, and Bielefeld University, University Hospital OWL, Protestant Hospital of Bethel Foundation, University Clinic of Psychiatry and Psychotherapy, and German Center for Mental Health (Nitsche); Temerty Centre for Therapeutic Brain Intervention and Campbell Family Research Institute, Centre for Addiction and Mental Health (CAMH) and Department of Psychiatry, University of Toronto, Toronto (Blumberger); Department of Medicine (Bolduc) and Department of Psychiatry and Addictology (Lespérance, Miron), Faculty of Medicine, University of Montreal, Montreal; Interventional Psychiatry Program, Department of Psychiatry, UC San Diego School of Medicine, San Diego (Weissman, Appelbaum, Daskalakis, Poorganji, Miron).
间隔横直流刺激 (tDCS) 是对主要抑郁症的可行且安全的治疗方法,可显著降低症状. 建议在随机试验中进一步验证以确认这些有希望的发现.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 医疗器械 医疗器械
背景情况:
- 重度抑郁症 (MDD) 是一种普遍且使人虚弱的心理健康状况.
- 目前对MDD的治疗有局限性,需要探索新的治疗方法.
- 神经调节技术,如横直流刺激 (tDCS),提供潜在的替代治疗策略.
研究的目的:
- 研究大抑郁症 (MDD) 间隔跨直流刺激 (tDCS) 方案的可行性,安全性和初步治疗效果.
- 评估MDD患者在两周内进行的50次tDCS治疗的耐受性和潜在疗效.
主要方法:
- 一项前性开放标签研究招募了30名被诊断患有严重抑郁症的参与者.
- 参与者在2周的时间内接受了50次tDCS.
- 评估了可行性,安全性和耐受性,以及使用汉密尔顿抑郁评分表 (HAM-D-17,HAM-D-6) 和蒙哥马利-奥斯伯格抑郁评分表 (MADRS) 的抑郁症状严重程度,在基线和随访时.
主要成果:
- 该tDCS协议显示了高可行性,具有93.3%的保留率和99.7%的遵守率.
- 没有报告严重的不良事件;常见的副作用包括轻微的刺痛,和暂时的皮肤发红.
- 观察到抑郁症状的显著减少,HAM-D-17得分从基线下降到1周和4周的随访,MADRS的类似趋势.
结论:
- 研究的间隔tDCS协议是可行的,安全的,并且对主要抑郁症有很好的耐受性.
- 该方案导致抑郁症症状严重程度的显著降低.
- 未来的研究应该包括假控制的随机试验和神经生理学措施,以验证发现并探索潜在机制.
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