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Updated: May 30, 2025

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase
07:27

Direct Restart of a Replication Fork Stalled by a Head-On RNA Polymerase

Published on: April 29, 2010

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转录接近停止的DNA复制叉触发了核糖体DNA复制数的变化

Mariko Sasaki1,2,3, Takehiko Kobayashi3,4,5

  • 1Laboratory of Gene Quantity Biology, Center for Frontier Research, National Institute of Genetics, 1111 Yata, Mishima, Shizuoka411-8540, Japan.

Nucleic acids research
|January 29, 2025
PubMed
概括

组织素脱乙酶Sir2通过防止DNA双链断裂 (DSB) 末端切除来维持核糖体DNA (rDNR) 拷贝数. 丢失Sir2导致转录复制碰撞,诱导DSB和rDNA不稳定.

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