编程细胞死亡1表达在各种癌症中CD8+T细胞的预后意义:系统性审查和元分析
Zhiyong Wan1, Meng Cui2, Jia Yang2
1Department of General Practice, People's Hospital of Leshan, Leshan, China.
Frontiers in oncology
|January 29, 2025
概括
在CD8+T细胞上增加编程细胞死亡蛋白1 (PD-1) 可能表明癌症患者的生存率较差. 这一元分析表明PD-1+CD8+T细胞可以作为恶性瘤的预后标志物.
科学领域:
- 在瘤学瘤学.
- 免疫学 免疫学 免疫学
- 癌症研究 癌症研究
背景情况:
- 编程细胞死亡蛋白1 (PD-1) 在CD8+T细胞上的表达是已知的T细胞耗尽的指标.
- 它与癌症患者预后的关联仍然存在争议,因为研究结果相互矛盾.
- 这项研究解决了对PD-1+CD8+T细胞作为人类癌症预后生物标志物的全面评估的需求.
研究的目的:
- 进行一个元分析,评估PD-1+CD8+T细胞在人类癌症中的预后价值.
- 综合现有证据关于PD-1+CD8+T细胞表达和患者生存结果之间的关联.
- 确定PD-1+CD8+T细胞是否可以在临床实践中可靠地用作预后标记物.
主要方法:
- 按照PRISMA指南进行了系统的元分析.
- 在PubMed,Web of Science和Embase数据库中进行文献搜索,截至2024年11月.
- 聚合危险比率 (HR) 和95%信心区间 (CI) 计算了总生存 (OS),无进展生存 (PFS) 和无疾病生存 (DFS).
- 根据各种因素进行亚组分析,包括癌症类型,样本和检测方法.
主要成果:
- 分析包括20项研究,包括23个队列和3086名癌症患者.
- 提升的PD-1+CD8+T细胞显示出预测较差的OS (HR: 1.379,p=0.009) 和不利的DFS (HR: 1.468,p=0.099) 的趋势.
- 对DFS没有达到统计显著性,但趋势表明了潜在的关联.
- 评估了出版偏差,并发现不显著.
结论:
- 在CD8+T细胞上高PD-1表达与癌症患者的生存结果较差有关.
- PD-1+CD8+T细胞显示出作为恶性瘤的预后标记物的潜力.
- 进一步的研究可能会巩固其在癌症预后中的临床实用性.
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