在中年和晚年,基于蛋白质组的衰老时钟和痴呆症风险
Sanaz Sedaghat1, Saeun Park1, Rob Walker1
1University of Minnesota.
Research square
|January 29, 2025
概括
通过蛋白质老化时钟测量的加速生物年龄与认知功能下降和中年和晚年痴呆症风险增加有关. 这一发现突出了蛋白质组.
科学领域:
- 衰老的生物标志物
- 蛋白质组学是指蛋白质组学.
- 神经退行性疾病 神经退行性疾病
背景情况:
- 生物年龄,即生理衰老的衡量标准,可以使用称为衰老时钟的蛋白质分数来评估.
- 生物年龄加速 (AA) 表示个体的生物年龄和时间年龄之间的差异.
研究的目的:
- 研究生物衰老加速 (AA) 与认知功能之间的关联.
- 为了确定AA是否预测中年和晚年个体发展痴呆症的风险.
主要方法:
- 利用了两个基于人口的队列:社区动脉样硬化风险研究 (ARIC) 和动脉样硬化多民族研究 (MESA).
- 使用弹性净回归模型开发和验证基于蛋白质学的衰老时钟 (PAC).
- 计算了年龄加速 (AA) 并使用多变量回归模型评估其与认知功能和痴呆发病率的关联.
主要成果:
- 每五年一次的AA与中年和晚年ARIC参与者的全球认知功能下降有关.
- 中年和晚年AA与更高的痴呆风险有关,晚年AA的相关性更为突出.
- 在MESA研究中观察到一致的结果,将AA与较低的认知功能和较高的痴呆风险联系起来.
结论:
- 由血蛋白质组决定的加速生物年龄与认知功能下降有显著的关联.
- 基于蛋白质基因的年龄加速是痴呆风险增加的预测因素,特别是在晚年.
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