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Updated: May 30, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

228

一种基于计算化学的方法来优化PD-1/PD-L1抑制剂

Meijuan Zhai1, Shiliang Ji2, Haoran Hu3

  • 1Department of pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University (Suzhou Municipal Hospital), Gusu School, Nanjing Medical University, Suzhou, China.

Frontiers in chemistry
|January 29, 2025
PubMed
概括

这项研究设计了新的小分子抑制剂,针对编程细胞死亡蛋白1 (PD-1) /编程死亡连接体1 (PD-L1) 途径. 化合物N2表现出显著的抑制活性,达到68.53%的抑制率,为未来的药物发现提供了基础.

关键词:
这是一种PD-1抑制剂.这是一种PD-L1抑制剂.计算机辅助药物设计分子对接的分子对接.非小细胞肺癌的肺癌.

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