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在安大略省的C型肝炎病毒血清流行,发病率和查模式 暴露前预防 用户
Matthew W McGarrity1,2, Ryan Lisk3, Paul MacPherson4,5,6
1Division of Infectious Diseases, St Michael's Hospital, Toronto, Canada.
Open forum infectious diseases
|January 29, 2025
概括
肝炎C病毒 (HCV) 感染在使用HIV暴露前预防 (PrEP) 与男性发生性关系的男性 (MSM) 中越来越令人担忧. 虽然加拿大安大略省的血清流行率和发病率较低,但检测率低于最佳水平,这表明需要改进查策略.
科学领域:
- 传染性疾病 传染性疾病
- 公共卫生 公共卫生
- 流行病学 流行病学
背景情况:
- 型肝炎病毒 (HCV) 越来越被认为是同性恋,双性恋和其他与男性发生性关系的男性 (GBM) 社区中的性传播感染.
- 使用人类免疫缺陷病毒暴露前预防 (PrEP) 的同性恋,双性恋和其他与男性发生性关系的男性是监测HCV传播动态的关键人群.
研究的目的:
- 在加拿大安大略省使用PrEP的GBM中估计HCV感染的血清流行率和发病率.
- 在这个人群中检查HCV检测的模式和充分性.
主要方法:
- 来自前性的安大略省PrEP队列研究 (ON-PrEP) 数据的分析.
- 包括557名符合条件的PrEP使用者,每两年收集两年的数据.
- 两变量分析以探索与HCV感染相关的社会人口统计学和临床因素.
主要成果:
- 在基线时,HCV血清流行率为1.3% (5/382).
- 在随访期间,HCV发病率为每100人年0.47人 (2/428.9人年).
- 只有43.9%的参与者接受了后续HCV抗体测试,第一次测试的中位数时间为245天.
结论:
- 在安大略省PrEP使用者中,HCV血清发病率和发病率低但显著.
- 肝炎病毒抗体和RNA检测率低于最佳,突出显示了推查方案中的差距.
- 进一步研究优化HCV查和预防策略在这个人口群体是有必要的.
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