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Updated: May 30, 2025

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联合TITE-CRM:对于具有迟发安全性和活动结果的疗法进行剂量检测研究的设计

Helen Barnett1,2, Oliver Boix3, Dimitris Kontos3,4

  • 1MRC Biostatistics Unit, University of Cambridge, Cambridge, UK.

Statistics in biopharmaceutical research
|January 29, 2025
PubMed
概括

本研究引入了联合时间到事件连续重新评估方法 (TITE-CRM),用于在癌症试验中找到最佳生物剂量 (OBD). 新方法有效地处理晚发性毒性和活性,优于现有设计.

关键词:
剂量确定方法晚期发作的活动活动.晚期发生的毒性.基于模型的模型.第一阶段试验试验.

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